KIAA1958 Antibody (G-12): sc-390319

KIAA1958 Antibody (G-12) is a mouse monoclonal IgM antibody that detects KIAA1958 protein of human origin, E130308A19Rik protein of mouse origin, and the corresponding rat homolog by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KIAA1958 antibody (G-12) is available as a non-conjugated format. KIAA1958 protein, consisting of 716 amino acids, is an uncharacterized protein that exists in three alternatively spliced isoforms. KIAA1958 is encoded by a gene located on human chromosome 9q32 and mouse chromosome 4 B3, with chromosome 9 housing over 900 genes and comprising nearly 4% of the human genome. KIAA1958′s significance lies in its potential role in various cellular processes, although specific functions remain to be fully elucidated. Notably, chromosome 9 is associated with hereditary hemorrhagic telangiectasia, characterized by harmful vascular defects, and familial dysautonomia, highlighting the importance of understanding the proteins encoded by this chromosome. Additionally, chromosome 9 encompasses the largest interferon family gene cluster, suggesting KIAA1958 may play a role in immune responses or cellular signaling pathways.

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KIAA1958 Antibody (G-12) References:

1. Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.  |  Zhuang, H., et al. 2006. Arthritis Rheum. 54: 1573-9. PMID: 16645992
2. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
3. Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.  |  Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
4. Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis.  |  Engelmark, MT., et al. 2008. Hum Genet. 123: 437-43. PMID: 18392855
5. Loss of heterozygosity at 9q32-33 (DBC1 locus) in primary non-invasive papillary urothelial neoplasm of low malignant potential and low-grade urothelial carcinoma of the bladder and their associated normal urothelium.  |  Lopez-Beltran, A., et al. 2008. J Pathol. 215: 263-72. PMID: 18452128
6. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing.  |  Gold-von Simson, G., et al. 2009. Pediatr Res. 65: 341-6. PMID: 19033881
7. Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells.  |  Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
8. Neuroimaging supports central pathology in familial dysautonomia.  |  Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
9. Crypton transposons: identification of new diverse families and ancient domestication events.  |  Kojima, KK. and Jurka, J. 2011. Mob DNA. 2: 12. PMID: 22011512
10. Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?  |  Zuffardi, O., et al. 1989. Hum Genet. 82: 17-9. PMID: 2541064
11. Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.  |  Hayden, LP., et al. 2018. Respir Res. 19: 209. PMID: 30373671
12. Molecular cytogenetic studies of duplication 9q32-->q34.3 inserted into 9q13.  |  Hou, JW. and Wang, TR. 1995. Clin Genet. 48: 148-50. PMID: 8556822

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIAA1958 Antibody (G-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KIAA1958 Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIAA1958 Antibody (G-12) Specifications

Alternate Product Name: KIAA1958

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 76-95

Epitope Target: KIAA1958

Epitope Species: human

Product Reactivity/Detection: KIAA1958 of human origin, E130308A19Rik of mouse origin and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KIAA1958 Antibody (G-12): P: Blocking Peptide