Ketorolac (tromethamine salt) (CAS 74103-07-4)
See product citations (4)
QUICK LINKS
Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 muM), rat Cox-2 (IC50 of 2.06 muM), human Cox-1 (IC50 of 1.23 muM) and human Cox-2 (IC50 of 3.50 muM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 muM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 muM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 muM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 muM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 muM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.
Ketorolac (tromethamine salt) (CAS 74103-07-4) References
- Clinical pharmacokinetics of ketorolac tromethamine. | Brocks, DR. and Jamali, F. 1992. Clin Pharmacokinet. 23: 415-27. PMID: 1458761
- Ketorolac tromethamine liposomes: encapsulation and release studies. | Ruozi, B., et al. 2005. J Liposome Res. 15: 175-85. PMID: 16393909
- Development and validation of a high-performance thin-layer chromatographic method, with densitometry, for quantitative analysis of ketorolac tromethamine in human plasma. | López-Bojórquez, E., et al. 2008. J AOAC Int. 91: 1191-5. PMID: 18980140
- Ketorolac tromethamine formulations: an overview. | Sinha, VR., et al. 2009. Expert Opin Drug Deliv. 6: 961-75. PMID: 19663721
- Compatibility and stability of binary mixtures of ketorolac tromethamine and tramadol hydrochloride injection concentrate and diluted infusion solution. | Lin, TF., et al. 2010. Acta Anaesthesiol Taiwan. 48: 117-21. PMID: 20864059
- Compatibility of ketorolac tromethamine injection with common infusion fluids and administration sets. | Floy, BJ., et al. 1990. Am J Hosp Pharm. 47: 1097-100. PMID: 2337102
- Stability of ketorolac tromethamine in 5% dextrose injection and 0.9% sodium chloride injections. | Gupta, VD., et al. 1997. Int J Pharm Compd. 1: 206-7. PMID: 23989215
- Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury. | Nadal-Nicolás, FM., et al. 2016. Invest Ophthalmol Vis Sci. 57: 1183-92. PMID: 26975030
- Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. | Cantarella, RA., et al. 2017. Open Vet J. 7: 254-260. PMID: 28884078
- Injectable thermoresponsive gels offer sustained dual release of bupivacaine hydrochloride and ketorolac tromethamine for up to two weeks. | Abdeltawab, H., et al. 2021. Int J Pharm. 604: 120748. PMID: 34051318
- The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt. | Rooks, WH., et al. 1985. Drugs Exp Clin Res. 11: 479-92. PMID: 3879752
- Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. | Laneuville, O., et al. 1994. J Pharmacol Exp Ther. 271: 927-34. PMID: 7965814
- Approaches for improving the stability of ketorolac in powder blends. | Brandl, M., et al. 1995. J Pharm Sci. 84: 1151-3. PMID: 8801326
- Evaluation of the financial impact of ketorolac tromethamine therapy in hospitalized patients. | Burke, JP., et al. 1996. Clin Ther. 18: 197-211. PMID: 8851463
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ketorolac (tromethamine salt), 500 mg | sc-205360 | 500 mg | $20.00 | |||
Ketorolac (tromethamine salt), 1 g | sc-205360A | 1 g | $52.00 |