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Ketoprofen Lysinate (CAS 57469-78-0)

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Alternate Names:
Lysyl-ketoprofen; Ketoprofen lysine salt
CAS Number:
57469-78-0
Molecular Weight:
400.47
Molecular Formula:
C22H28N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ketoprofen lysinate, as a water-soluble salt form of ketoprofen, offers a unique approach in the modulation of biochemical pathways, particularly through its inhibition of prostaglandin synthesis. This action is in the study of inflammation and pain at the molecular level, as prostaglandins are pivotal mediators in these processes. By targeting the cyclooxygenase enzymes (COX-1 and COX-2), ketoprofen lysinate serves as useful in research, offering insights into the complex mechanisms underlying inflammatory responses. This inhibition not only elucidates the roles of prostaglandins but also aids in understanding the balance between the enzyme′s constitutive and inducible forms, providing a nuanced view of cellular and molecular responses to inflammatory stimuli. Consequently, its water-soluble nature enhances its applicability in various experimental applications, allowing for a more efficient exploration of its effects in biochemical assays and studies focused on the pathophysiology of inflammation.


Ketoprofen Lysinate (CAS 57469-78-0) References

  1. Protective effect of ketoprofen lysine salt on interleukin-1beta and bradykinin induced inflammatory changes in hamster cheek pouch microcirculation.  |  Daffonchio, L., et al. 2002. Inflamm Res. 51: 223-8. PMID: 12056509
  2. Effective prevention of 5-fluorouracil-induced superficial phlebitis by ketoprofen lysine salt gel.  |  Berardi, R., et al. 2003. Am J Med. 115: 415-7. PMID: 14553886
  3. Encapsulation of ketoprofen and ketoprofen lysinate by prilling for controlled drug release.  |  Del Gaudio, P., et al. 2009. AAPS PharmSciTech. 10: 1178-85. PMID: 19856108
  4. Design of alginate-based aerogel for nonsteroidal anti-inflammatory drugs controlled delivery systems using prilling and supercritical-assisted drying.  |  Gaudio, PD., et al. 2013. J Pharm Sci. 102: 185-94. PMID: 23150457
  5. Non-steroidal anti-inflammatory drug for pulmonary administration: design and investigation of ketoprofen lysinate fine dry powders.  |  Stigliani, M., et al. 2013. Int J Pharm. 448: 198-204. PMID: 23528281
  6. Nanospray drying as a novel technique for the manufacturing of inhalable NSAID powders.  |  Aquino, RP., et al. 2014. ScientificWorldJournal. 2014: 838410. PMID: 25580462
  7. Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt.  |  Cerciello, A., et al. 2016. Drug Dev Ind Pharm. 42: 2063-2069. PMID: 27237337
  8. Efficacy of ketoprofen lysine salt and paracetamol/acetaminophen to reduce pain during rapid maxillary expansion: A randomized controlled clinical trial.  |  Cossellu, G., et al. 2019. Int J Paediatr Dent. 29: 58-65. PMID: 30298560
  9. The effect of ketoprofen lysine salt on mucosa of rat stomach after ethyl alcohol intoxication.  |  Kuczyńska, J. and Nieradko-Iwanicka, B. 2021. Biomed Pharmacother. 141: 111938. PMID: 34328086
  10. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog.  |  Novelli, R., et al. 2022. Biomed Pharmacother. 153: 113336. PMID: 35772374
  11. FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field.  |  Pullano, SA., et al. 2022. Bioengineering (Basel). 9: PMID: 36290471
  12. Comparison of the effects of ketoprofen and ketoprofen lysine salt on the Wistar rats' nervous system, kidneys and liver after ethyl alcohol intoxication.  |  Kuczyńska, J. and Nieradko-Iwanicka, B. 2023. Biomed Pharmacother. 161: 114456. PMID: 36870283
  13. Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.  |  Daffonchio, L., et al. 1995. Arzneimittelforschung. 45: 590-4. PMID: 7541996
  14. Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness.  |  Asti, C., et al. 1995. Pharmacol Res. 31: 387-92. PMID: 8685078
  15. Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat.  |  Fiorentino, S., et al. 1996. Pharmacol Res. 33: 277-81. PMID: 8938021

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ketoprofen Lysinate, 25 mg

sc-492073A
25 mg
$168.00

Ketoprofen Lysinate, 100 mg

sc-492073
100 mg
$469.00

Ketoprofen Lysinate, 1 g

sc-492073B
1 g
$1244.00