Molecular structure of Ketoprofen, CAS Number: 22071-15-4
Ketoprofen (CAS 22071-15-4)
See product citations (2)
Alternate Names:
2-(3-benzoylphenyl)propionic acid
Application:
Ketoprofen is an inhibitor of Cox-1 and Cox-2
CAS Number:
22071-15-4
Purity:
>99%
Molecular Weight:
254.28
Molecular Formula:
C16H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ketoprofen functions as a potent inhibitor of the enzyme cyclooxygenase. This inhibition prevents the conversion of arachidonic acid to prostaglandin H2, thereby reducing the production of prostaglandins. At the molecular level, ketoprofen binds to the active site of the COX enzymes, interfering with the catalytic activity and ultimately disrupting the synthesis of prostaglandins. This mechanism of action makes ketoprofen useful in investigating the molecular pathways involved in inflammation and pain, as well as for studying the role of prostaglandins in various physiological and pathological processes.
Ketoprofen (CAS 22071-15-4) References
- Encapsulation of ketoprofen and ketoprofen lysinate by prilling for controlled drug release. | Del Gaudio, P., et al. 2009. AAPS PharmSciTech. 10: 1178-85. PMID: 19856108
- Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients. | Kokki, H. 2010. Paediatr Drugs. 12: 313-29. PMID: 20799760
- Ketoprofen removal by O₃ and O₃/UV processes: kinetics, transformation products and ecotoxicity. | Illés, E., et al. 2014. Sci Total Environ. 472: 178-84. PMID: 24291560
- Ketoprofen-induced photoallergic dermatitis. | Loh, TY. and Cohen, PR. 2016. Indian J Med Res. 144: 803-806. PMID: 28474616
- Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen. | Toledo, MV. and Briand, LE. 2018. Crit Rev Biotechnol. 38: 778-800. PMID: 29124963
- Targeted eco-pharmacovigilance for ketoprofen in the environment: Need, strategy and challenge. | Wang, J., et al. 2018. Chemosphere. 194: 450-462. PMID: 29227893
- Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders. | Thibault, MP., et al. 2019. J Pediatr Gastroenterol Nutr. 68: 623-629. PMID: 31022092
- Solubility and thermodynamic analysis of ketoprofen in organic solvents. | Soto, R., et al. 2020. Int J Pharm. 588: 119686. PMID: 32739387
- Radical reactions induced by ketoprofen in phospholipid membranes under ultraviolet light irradiation. | Okazaki, S., et al. 2021. J Photochem Photobiol B. 214: 112090. PMID: 33302245
- Anti-quorum sensing potential of ketoprofen and its derivatives against Pseudomonas aeruginosa: insights to in silico and in vitro studies. | Tajani, AS., et al. 2021. Arch Microbiol. 203: 5123-5132. PMID: 34319419
- Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking. | Nixon, E., et al. 2022. J Vet Pharmacol Ther. 45: 450-466. PMID: 35833463
- Ketoprofen suppresses triple negative breast cancer cell growth by inducing apoptosis and inhibiting autophagy. | Patra, I., et al. 2023. Mol Biol Rep. 50: 85-95. PMID: 36309613
- Ketoprofen extended-release capsules: a new formulation for the treatment of osteoarthritis and rheumatoid arthritis. | Schumacher, HR. 1994. Clin Ther. 16: 145-59. PMID: 8062310
Inhibitor of:
9530003J23Rik, AKR1C19, AKR1C20, C6, Cox, Cox-2, EPX, Factor XII, OAT2, OAT3, OAT6, SLC22A11, Slc22a27, UGT1A3, and UGT2B.Activator of:
AKR1C19, AKR1C6, and MRP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ketoprofen, 5 g | sc-205359 | 5 g | $93.00 | |||
Ketoprofen, 25 g | sc-205359A | 25 g | $308.00 |