Ketoconazole-d8 (CAS 1217706-96-1)

Ketoconazole-d8 is a deuterated form of ketoconazole used extensively in research applications that require a stable isotopic label. The presence of deuterium, a stable isotope of hydrogen, makes this compound particularly useful in mass spectrometry as an internal standard. This allows for more accurate quantification and analysis of ketoconazole in various samples. Researchers utilize ketoconazole-d8 in studies of metabolic pathways involving cytochrome P450 enzymes, as ketoconazole is a known inhibitor of these enzymes. By employing this deuterated compound, scientists can investigate the metabolic fate of ketoconazole and similar substances in biological systems. Additionally, ketoconazole-d8 facilitates the study of chemical interactions and the impact of ketoconazole on the metabolism of other compounds. The use of a deuterated standard such as ketoconazole-d8 ensures precision and reliability in analytical experiments where minute details and differences in mass are critical.