Keratinocyte Differentiation Inducer (CAS 863598-09-8)
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The cell-permeable pyrrolo-pyrimidone compound serves as a potent inhibitor of casein kinase II, with an IC50 value of 9 nM, and effectively induces differentiation in normal human keratinocytes, with an EC50 of 100 nM. Beyond its inhibitory action, this compound has demonstrated interactions with cellular elements such as TANK-binding kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9), either directly or indirectly. In the context of dermatological research, the keratinocyte differentiation inducer is instrumental in promoting the maturation of keratinocytes, which are for forming the skin′s protective layer. By activating specific signaling pathways through keratinocyte growth factor receptors, this inducer triggers gene expression changes that culminate in keratinocyte differentiation and the production of keratin, contributing to our understanding of processes like wound healing and skin immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Keratinocyte Differentiation Inducer, 5 mg | sc-311368 | 5 mg | $412.00 |