Keratin 81 Antibody (36-Z): sc-100929

Keratin 81 Antibody (36-Z) is a mouse monoclonal IgG2b kappa light chain antibody that detects Keratin 81 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Keratin 81 antibody (36-Z) is available as the non-conjugated format. Keratin 81, also known as KRTHB1, MLN137, HB1, or Hb-1, is a type II hair keratin composed of 505 amino acids and is predominantly expressed in the cortex of growing hair. Keratin 81 plays a crucial role in the structural integrity and resilience of hair fibers, as Keratin 81 forms part of the heterotetramer structure that includes two type I and two type II keratins, essential for the assembly of hair and nail fibers. Proper functioning of Keratin 81 is vital, as mutations in the gene encoding Keratin 81 can lead to Monilethrix, an autosomal dominant hair disorder characterized by patches of thin, easily breakable hair on the scalp, eyebrows, and eyelashes. The keratin multigene family, which includes Keratin 81, is divided into "soft" epithelial cytokeratins and "hard" hair keratins, with the former contributing to the formation and layering of epithelial tissues. Keratin 81 monoclonal antibody (36-Z) effectively detects this important protein across various applications, making Keratin 81 (36-Z) antibody a valuable tool for researchers studying hair biology and related disorders.

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Keratin 81 Antibody (36-Z) References:

1. Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.  |  Rogers, MA., et al. 2000. J Invest Dermatol. 114: 464-72. PMID: 10692104
2. 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments.  |  Coulombe, PA. and Omary, MB. 2002. Curr Opin Cell Biol. 14: 110-22. PMID: 11792552
3. Keratins of the human hair follicle.  |  Langbein, L. and Schweizer, J. 2005. Int Rev Cytol. 243: 1-78. PMID: 15797458
4. New consensus nomenclature for mammalian keratins.  |  Schweizer, J., et al. 2006. J Cell Biol. 174: 169-74. PMID: 16831889
5. Sequence data and chromosomal localization of human type I and type II hair keratin genes.  |  Rogers, MA., et al. 1995. Exp Cell Res. 220: 357-62. PMID: 7556444
6. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.  |  Winter, H., et al. 1997. Hum Genet. 101: 165-9. PMID: 9402962
7. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.  |  Bowden, PE., et al. 1998. J Invest Dermatol. 110: 158-64. PMID: 9457912
8. A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.  |  Winter, H., et al. 1998. J Invest Dermatol. 111: 169-72. PMID: 9665406

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Keratin 81 Antibody (36-Z) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Keratin 81 Antibody (36-Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Keratin 81 Antibody (36-Z) Specifications

Alternate Product Name: Keratin 81

Product Clone Name: 36-Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-203

Epitope Target: Keratin 81

Epitope Species: human

Product Reactivity/Detection: Keratin 81

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Keratin 81 Antibody (36-Z): N/A