Keratan sulfate Antibody (4B3/D10): sc-73518
- Keratan sulfate Antibody (4B3/D10) is a mouse monoclonal IgG1 Keratan sulfate antibody, cited in 11 publications, provided at 50 µg/500 µl
- raised against purified aggrecan of human origin
- recommended for detection of Keratan sulfate glycosaminoglycan chains of human origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Keratan sulfate Antibody (4B3/D10). This work is in progress.
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Keratan sulfate Antibody (4B3/D10) is a mouse monoclonal IgG1 antibody that detects Keratan sulfate protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Keratan sulfate antibody (4B3/D10) is available as a non-conjugated format. Keratan sulfate is a crucial component of proteoglycans, which are essential for maintaining structural integrity and function of various tissues, including brain, cartilage, and cornea. These proteoglycans are characterized by elongated glycosaminoglycan chains, which play a significant role in cell signaling and regulation of cellular activities. Keratan sulfate in the extracellular matrix influences cell adhesion, migration, and proliferation, contributing to tissue repair and regeneration processes. Keratan sulfate proteoglycans are secreted into synovial fluid and serum during tissue repair in response to joint or inflammatory diseases, making these proteins potential biomarkers for early detection of degenerative cartilage and joint breakdown. Keratan sulfate interactions with various proteins in the extracellular matrix underscore its importance in modulating cellular responses and maintaining tissue homeostasis.
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Keratan sulfate Antibody (4B3/D10) References:
- Multistage mass spectrometric sequencing of keratan sulfate-related oligosaccharides. | Minamisawa, T., et al. 2006. Anal Chem. 78: 891-900. PMID: 16448065
- Keratan sulfate and chondroitin/dermatan sulfate in maximally recovered hypocellular stromal interface scars of postmortem human LASIK corneas. | Zhang, Y., et al. 2006. Invest Ophthalmol Vis Sci. 47: 2390-6. PMID: 16723448
- Chondroitin sulfate and keratan sulfate are the major glycosaminoglycans present in the adult zebrafish Danio rerio (Chordata-Cyprinidae). | Souza, AR., et al. 2007. Glycoconj J. 24: 521-30. PMID: 17541818
- Keratan sulfate glycosaminoglycan and the association with collagen fibrils in rudimentary lamellae in the developing avian cornea. | Young, RD., et al. 2007. Invest Ophthalmol Vis Sci. 48: 3083-8. PMID: 17591877
- Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. | Kitayama, K., et al. 2007. J Biol Chem. 282: 30085-96. PMID: 17690104
- Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage. | Sharma, A., et al. 2007. Arthritis Res Ther. 9: R79. PMID: 17697352
- Keratanase II-catalyzed synthesis of keratan sulfate oligomers by using sugar oxazolines as transition-state analogue substrate monomers: a novel insight into the enzymatic catalysis mechanism. | Ohmae, M., et al. 2007. Chembiochem. 8: 1710-20. PMID: 17705309
- Serum keratan sulfate is a promising marker of early articular cartilage breakdown. | Wakitani, S., et al. 2007. Rheumatology (Oxford). 46: 1652-6. PMID: 17855425
- Expression of different proteoglycans in human breast tumors. | Eshchenko, TY., et al. 2007. Biochemistry (Mosc). 72: 1016-20. PMID: 17922662
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Keratan sulfate Antibody (4B3/D10) | sc-73518 | 50 µg/500 µl | $316.00 |