Date published: 2025-10-16

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KDdiA-PC Solution (CAS 439904-34-4)

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Alternate Names:
1-palmitoyl-2-(4-keto-dodec-3-ene-dioyl)phosphatidylcholine
Application:
KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species
CAS Number:
439904-34-4
Molecular Weight:
719.9
Molecular Formula:
C36H66NO11P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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KDdiA-PC, with the CAS number 439904-34-4, is a specialized phosphatidylcholine (PC) derivative known for its incorporation of ketodeoxyoctulosonic acid (KDdiA) linked to a phospholipid backbone. This complex molecular structure makes KDdiA-PC a focal point in research pertaining to membrane biology and lipid-mediated signaling. The compound′s unique feature lies in its KDdiA component, a carbohydrate derivative, which introduces distinct chemical properties and biological activities. In research settings, KDdiA-PC has been utilized to study the interactions between carbohydrates and lipids within cellular membranes and their impact on the physicochemical properties of the membrane, such as fluidity, phase behavior, and interaction with proteins. Its usage extends to probing the role of modified phospholipids in modulating cellular signaling pathways, particularly those involved in cell recognition and immune response. By incorporating KDdiA into the PC structure, researchers can explore how changes in membrane composition influence cellular communication and metabolic responses. This research provides insights into the fundamental processes of membrane dynamics and lipid signaling, offering a deeper understanding of the molecular interactions that govern cell function and behavior in complex biological systems.


KDdiA-PC Solution (CAS 439904-34-4) References

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  2. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36.  |  Podrez, EA., et al. 2002. J Biol Chem. 277: 38503-16. PMID: 12105195
  3. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.  |  Podrez, EA., et al. 2002. J Biol Chem. 277: 38517-23. PMID: 12145296
  4. Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36.  |  Kar, NS., et al. 2008. J Biol Chem. 283: 8765-71. PMID: 18245080
  5. Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters.  |  Ashraf, MZ., et al. 2008. J Biol Chem. 283: 10408-14. PMID: 18285332
  6. Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles.  |  Kar, S., et al. 2011. Chem Phys Lipids. 164: 54-61. PMID: 21074521
  7. Analysis of relationship between oxidized phospholipid structure and interaction with the class B scavenger receptors.  |  Gao, D., et al. 2015. Methods Mol Biol. 1208: 29-48. PMID: 25323497
  8. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases.  |  Lu, J., et al. 2017. Redox Biol. 12: 899-907. PMID: 28472752
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

KDdiA-PC Solution, 500 µg

sc-224032
500 µg
$82.00

KDdiA-PC Solution, 1 mg

sc-224032A
1 mg
$152.00