KD 5170 (CAS 940943-37-3)
Available in US only.
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KD 5170 is an inhibitor of HDAC6 (IC50 = 0.014 muM), HDAC1 (IC50 = 0.020 muM), HDAC4 (IC50 = 0.026 muM), HDAC3 (IC50 = 0.075 muM), and HDAC2 (IC50 = 2.0 muM). KD 51570 exhibits broad spectrum inhibition of HDAC classes I and II in assays using purified recombinant human isoforms. KD 5170 is a chemical compound extensively utilized in scientific research. It possesses the remarkable capability to impede the Notch signaling pathway, which plays a vital role in regulating cell differentiation, proliferation, and apoptosis. Researchers have effectively employed KD 5170 as a potent inhibitor of the Notch pathway in numerous studies aimed at exploring the significance of Notch signaling in various biological processes.
KD 5170 (CAS 940943-37-3) References
- KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. | Hassig, CA., et al. 2008. Mol Cancer Ther. 7: 1054-65. PMID: 18483295
- KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling. | Feng, R., et al. 2008. Mol Cancer Ther. 7: 1494-505. PMID: 18566220
- Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor. | Payne, JE., et al. 2008. Bioorg Med Chem Lett. 18: 6093-6. PMID: 18954983
- Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina. | Bagnall, NH., et al. 2017. Int J Parasitol Drugs Drug Resist. 7: 51-60. PMID: 28110187
- Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer. | Ishigami-Yuasa, M., et al. 2019. Biol Pharm Bull. 42: 448-452. PMID: 30828077
- Promising Anti-Mitochondrial Agents for Overcoming Acquired Drug Resistance in Multiple Myeloma. | Innao, V., et al. 2021. Cells. 10: PMID: 33669515
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KD 5170, 10 mg | sc-362755 | 10 mg | $398.00 | |||
| US: Only available in the US | ||||||