KCTD4 Antibody (NN-07): sc-100998

KCTD4 Antibody (NN-07) is a mouse monoclonal IgG2b kappa light chain antibody that detects KCTD4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KCTD4 antibody (NN-07) is available as a non-conjugated format. KCTD4 protein consists of 259 amino acids and features a BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as a POZ (POxvirus and Zinc finger) domain, playing a crucial role in homodimerization and is characterized by multiple kelch repeats and/or C2H2-type zinc fingers. This structural feature suggests KCTD4 may function as a transcriptional regulator, influencing gene expression by modulating chromatin structure and function. KCTD4′s ability to interact with various proteins involved in transcriptional regulation highlights KCTD4′s importance in cellular processes, including development and differentiation. KCTD4 monoclonal antibody (NN-07) enables researchers to gain valuable insights into regulatory mechanisms of gene expression and potential implications in various biological contexts.

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KCTD4 Antibody (NN-07) References:

1. Towards a proteome-scale map of the human protein-protein interaction network.  |  Rual, JF., et al. 2005. Nature. 437: 1173-8. PMID: 16189514
2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.  |  Kimura, K., et al. 2006. Genome Res. 16: 55-65. PMID: 16344560
3. Pentameric assembly of potassium channel tetramerization domain-containing protein 5.  |  Dementieva, IS., et al. 2009. J Mol Biol. 387: 175-91. PMID: 19361449
4. PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats.  |  Huang, T., et al. 2012. Biochem Biophys Res Commun. 417: 182-6. PMID: 22138399
5. Identification of new genes of pleomorphic adenoma.  |  Choi, JS., et al. 2019. Medicine (Baltimore). 98: e18468. PMID: 31861025
6. Evaluation of cfDNA as an early detection assay for dense tissue breast cancer.  |  Barbirou, M., et al. 2022. Sci Rep. 12: 8458. PMID: 35589867
7. Alphafold Predictions Provide Insights into the Structural Features of the Functional Oligomers of All Members of the KCTD Family.  |  Esposito, L., et al. 2022. Int J Mol Sci. 23: PMID: 36362127
8. KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.  |  Zheng, C., et al. 2023. Acta Pharm Sin B. 13: 4217-4233. PMID: 37799381
9. Effects of Mitochondrial Transplantation on Transcriptomics in a Polymicrobial Sepsis Model.  |  Kim, S., et al. 2023. Int J Mol Sci. 24: PMID: 37895006
10. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.  |  Zollman, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 10717-21. PMID: 7938017
11. The POZ domain: a conserved protein-protein interaction motif.  |  Bardwell, VJ. and Treisman, R. 1994. Genes Dev. 8: 1664-77. PMID: 7958847
12. Crystal structure of the BTB domain from PLZF.  |  Ahmad, KF., et al. 1998. Proc Natl Acad Sci U S A. 95: 12123-8. PMID: 9770450

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KCTD4 Antibody (NN-07) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KCTD4 Antibody (NN-07) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KCTD4 Antibody (NN-07) Specifications

Alternate Product Name: KCTD4

Product Clone Name: NN-07

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-260

Epitope Target: KCTD4

Epitope Species: human

Product Reactivity/Detection: KCTD4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2b kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KCTD4 Antibody (NN-07): N/A