KCNH6 Antibody (46): sc-135959

KCNH6 Antibody (46) is a mouse monoclonal IgG1 antibody that detects KCNH6 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-KCNH6 antibody (46) is available as the non-conjugated format. KCNH6 protein, also known as potassium voltage-gated channel subfamily H member 6 or human ether-a-go-go potassium channel 2 (hEAG2), plays a critical role in regulating cellular excitability within the nervous system. KCNH6 (46) antibody targets an α subunit of a multi-pass transmembrane potassium channel, which is essential for forming the pore of the voltage-gated channel. The channel is typically composed of homo- or heterotetrameric structures formed by pore-forming α subunits that associate with modulating β subunits, allowing for precise control of ion flow across the membrane. KCNH6 is characterized by unique structural features, including one PAS-associated C-terminal (PAC) domain, one PER-ARNT-SIM (PAS) domain, and one cyclic nucleotide-binding domain, which are crucial for function and regulation. KCNH6 is expressed in prolactin-secreting adenomas and throughout the brain, highlighting importance in both normal physiology and potential pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KCNH6 Antibody (46) References:

1. The eag family of K+ channels in Drosophila and mammals.  |  Ganetzky, B., et al. 1999. Ann N Y Acad Sci. 868: 356-69. PMID: 10414305
2. HERG K(+) currents in human prolactin-secreting adenoma cells.  |  Bauer, CK., et al. 2003. Pflugers Arch. 445: 589-600. PMID: 12634931
3. Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system.  |  Papa, M., et al. 2003. J Comp Neurol. 466: 119-35. PMID: 14515244
4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.  |  Gutman, GA., et al. 2005. Pharmacol Rev. 57: 473-508. PMID: 16382104
5. The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.  |  Ferrer, T., et al. 2006. J Biol Chem. 281: 12858-64. PMID: 16524878
6. Quantitative structure-activity relationship studies on inhibition of HERG potassium channels.  |  Yoshida, K. and Niwa, T. 2006. J Chem Inf Model. 46: 1371-8. PMID: 16711756
7. Activation of ERG2 potassium channels by the diphenylurea NS1643.  |  Elmedyb, P., et al. 2007. Neuropharmacology. 53: 283-94. PMID: 17610913

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KCNH6 Antibody (46) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KCNH6 Antibody (46) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KCNH6 Antibody (46) Specifications

Alternate Product Name: KCNH6

Product Clone Name: 46

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 823-937

Epitope Target: KCNH6

Epitope Species: rat

Product Reactivity/Detection: KCNH6

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KCNH6 Antibody (46): N/A