kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673 (sc-205246). Reported to demonstrate prominent cytotoxic and anti-proliferative effects in vitro. Additionally noted to inhibit cell migration and invasion in a prostate cancer cell line. kb NB 142-70 is an inhibitor of PKC μ, PKC ν and PKD2.
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SinnettSinnett-Smith J; et al. (PubMed ID: 24647541) determined that kb NB 142-70 prevented ANG II-induced phosphorylation of HDAC4, HDAC5, and HDAC7 in IEC-18 cells. -SCBT Publication Review