kb NB 142-70 CAS: 1233533-04-4
MF: C11H9NO2S2
MW: 251.32
A potent & selective protein kinase D inhibitor.

kb NB 142-70 (CAS 1233533-04-4)

kb NB 142-70 | CAS 1233533-04-4 is rated 5.0 out of 5 by 1.
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Synonym: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
Application: A potent & selective protein kinase D inhibitor
CAS Number: 1233533-04-4
Purity: ≥98%
Molecular Weight: 251.32
Molecular Formula: C11H9NO2S2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673 (sc-205246). Reported to demonstrate prominent cytotoxic and anti-proliferative effects in vitro. Additionally noted to inhibit cell migration and invasion in a prostate cancer cell line. kb NB 142-70 is an inhibitor of PKC μ, PKC ν and PKD2.


References

1. LaValle, C.R., et al. 2010. BMC Chem. Biol. 10: 5. PMID: 20444281

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM ).
Storage :
Store at room temperature
Boiling Point :
601.94° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
PKD1: IC50 = 28.3 nM; PKD2: IC50 = 58.7 nM; PKD3: IC50 = 53.2 nM
pK Values :
pKa: 8.99 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
45258277
MDL Number :
MFCD18086915
SMILES :
C1CSC2=C(C(=O)N1)SC3=C2C=C(C=C3)O

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Certificate of Analysis

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kb NB 142-70  Product Citations

See how others have used kb NB 142-70. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26987843  Yoo, N. et al. 2016. Immunol. Lett. 173: 69-76.

PMID: # 26459638  Wortzel, I. et al. 2015. J. Cell. Sci. 128: 4083-95.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Sinnett Sinnett-Smith J; et al. (PubMed ID: 24647541) determined that kb NB 142-70 prevented ANG II-induced phosphorylation of HDAC4, HDAC5, and HDAC7 in IEC-18 cells. -SCBT Publication Review
Date published: 2015-05-22
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