Molecular structure of kb NB 142-70, CAS Number: 1233533-04-4
kb NB 142-70 (CAS 1233533-04-4)
See product citations (3)
Alternate Names:
3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
Application:
kb NB 142-70 is a potent & selective protein kinase D inhibitor
CAS Number:
1233533-04-4
Purity:
≥98%
Molecular Weight:
251.32
Molecular Formula:
C11H9NO2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673 (sc-205246). Reported to demonstrate prominent cytotoxic and anti-proliferative effects in vitro. Additionally noted to inhibit cell migration and invasion in a prostate cancer cell line. kb NB 142-70 is an inhibitor of PKC μ, PKC ν and PKD2.
kb NB 142-70 (CAS 1233533-04-4) References
- Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. | Lavalle, CR., et al. 2010. BMC Chem Biol. 10: 5. PMID: 20444281
- Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. | Young, SH., et al. 2012. Am J Physiol Gastrointest Liver Physiol. 303: G356-66. PMID: 22595992
- PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. | Ni, Y., et al. 2013. PLoS One. 8: e73149. PMID: 24039875
- Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. | Sinnett-Smith, J., et al. 2014. Am J Physiol Cell Physiol. 306: C961-71. PMID: 24647541
- PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester. | Ni, Y., et al. 2015. Int J Biochem Cell Biol. 60: 34-42. PMID: 25578563
- Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552. | Wang, J., et al. 2016. Am J Physiol Cell Physiol. 310: C542-57. PMID: 26739494
- Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). | Wang, J., et al. 2016. J Biol Chem. 291: 17988-8005. PMID: 27369082
- Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. | Hao, F., et al. 2017. Mol Cancer Res. 15: 929-941. PMID: 28360038
- Protein kinase D1 inhibition interferes with mitosis progression. | Martínez-León, E., et al. 2019. J Cell Physiol. 234: 20510-20519. PMID: 30997696
- Endothelial Protein kinase D1 is a major regulator of post-traumatic hyperinflammation. | Schönfelder, J., et al. 2023. Front Immunol. 14: 1093022. PMID: 36936923
Inhibitor of:
PKC ν, PKD2, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
kb NB 142-70, 10 mg | sc-358834 | 10 mg | $180.00 | |||
kb NB 142-70, 50 mg | sc-358834A | 50 mg | $750.00 |