Kazusamycin B CAS: 107140-30-7
MF: C32H46O7
MW: 542.7
A minor component of the leptomycin complex that displays anti-bacterial & anti-fungal activity.

Kazusamycin B (CAS 107140-30-7)

Kazusamycin B | CAS 107140-30-7 is rated 5.0 out of 5 by 1.
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Application: Kazusamycin B is a minor component of the leptomycin complex that displays anti-bacterial & anti-fungal activity
CAS Number: 107140-30-7
Purity: >95%
Molecular Weight: 542.7
Molecular Formula: C32H46O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Kazusamycin B is a minor component of the leptomycin complex produced from the fermentation of the broth of a Streptomyces sp.. The compound is a hydroxylated analogue of Leptomycin A (sc-203102), a nuclear export inhibitor, and highly lipophillic. In vitro antitumor activity of Kazusamycin B on tumors L1210, P388/S, B16, HeLa S3, L5178Y-ML or L929 was ascertained to have an IC50 of 1.8, 2.0, 0.7, 1.8, 10.0 and l.0 ng/ml when cultured in the presence of Kazusamycin B for 72 hours. The compound has also displayed broad antitumor activity in mice with effectiveness being more dependent on dosing regimen than dosing concentration both in vivo and in vitro. Kazusamycin B also possesses antibacterial and antifungal activity.


References

1. Yoshida, E., et al. 1987. J. Antibiot. 40: 1596-1604. PMID: 3693127
2. Funaishi, K., et al. 1987. J. Antibiot. 40: 778-785. PMID: 3610834
3. Takamiya, K., et al. 1988. J. Antibiot. 41: 1854-1861. PMID: 3209477

Appearance :
Film
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMSO, and DMF.
Storage :
Store at -20° C
IC50 :
B16: IC50 = 0.7 ng/ml; L929: IC50 = 1.0 ng/ml; Tumors L1210: IC50 = 1.8 ng/ml; HeLa S3: IC50 = 1.8 ng/ml; P388/S: IC50 = 2.0 ng/ml
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
OA0551000
PubChem CID :
6436293
MDL Number :
MFCD01716600
SMILES :
CC1C=CC(=O)OC1/C=C/C(=C\\C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O) O)/C)O)/C)/C

Download SDS (MSDS)

Certificate of Analysis

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PMID: # 3693127  Yoshida, E. et al. 1987. J. Antibiot. 40: 1596-1604.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yoshida Yoshida, E. et al. (PubMed 3693127) studied the antitumor effect of Kazusamycin B, that displays broad antitumor activity along with antibacterial and antifungal activity, on experimental tumors. IC50 against the growth of tumor cells was around 1 ng/ml at 72 hours exposure in vitro. -SCBT Publication Review
Date published: 2015-07-06
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