Kasugamycin Hydrochloride Monohydrate (CAS 200132-83-8)
See product citations (1)
QUICK LINKS
Kasugamycin Hydrochloride Monohydrate is a broad-spectrum aminoglycoside antibiotic that functions by inhibiting protein synthesis in bacteria. It achieves this by binding to the 30S subunit of the bacterial ribosome, thereby preventing the initiation complex formation and causing misreading of the mRNA. This disruption ultimately leads to the inhibition of protein synthesis, resulting in the bactericidal effect of Kasugamycin Hydrochloride Monohydrate. The mechanism of action involves the interference with the translocation process during protein synthesis, leading to the accumulation of incomplete or abnormal peptides within the bacterial cell. This disruption of protein synthesis ultimately leads to the inhibition of bacterial growth and reproduction.
Kasugamycin Hydrochloride Monohydrate (CAS 200132-83-8) References
- Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics. | Tamamura, T. and Sato, K. 1999. Jpn J Antibiot. 52: 57-67. PMID: 10202688
- Establishment of a new cross of the rice blast fungus derived from Japanese differential strain Ina168 and hermaphroditic rice pathogen Guy11. | Fukiya, S., et al. 2001. Biosci Biotechnol Biochem. 65: 1464-73. PMID: 11515527
- Differential inhibition of 30S and 70S translation initiation complexes on leaderless mRNA by kasugamycin. | Moll, I. and Bläsi, U. 2002. Biochem Biophys Res Commun. 297: 1021-1026. PMID: 12359258
- A NEW ANTIBIOTIC, KASUGSMYCIN. | UMEZAWA, H., et al. 1965. J Antibiot (Tokyo). 18: 101-3. PMID: 14326080
- The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. | Schluenzen, F., et al. 2006. Nat Struct Mol Biol. 13: 871-8. PMID: 16998488
- Translation initiation region dependency of translation initiation in Escherichia coli by IF1 and kasugamycin. | Surkov, S., et al. 2010. FEBS J. 277: 2428-39. PMID: 20477873
- Studies on biosynthesis of kasugamycin. I. Biosynthesis of kasugamycin and the kasugamine moiety. | Fukagawa, Y., et al. 1968. J Antibiot (Tokyo). 21: 50-4. PMID: 5673293
- Studies on biosynthesis of kasugamycin. 3. Biosynthesis of the d-inositol moiety. | Fukagawa, Y., et al. 1968. J Antibiot (Tokyo). 21: 185-8. PMID: 5673676
- Studies on biosynthesis of kasugamycin. V. Biosynthesis of the amidine group. | Fukagawa, Y., et al. 1968. J Antibiot (Tokyo). 21: 410-2. PMID: 5723083
- Protein folding in Escherichia coli: role of 23S ribosomal RNA. | Chattopadhyay, S., et al. 1999. Biochim Biophys Acta. 1429: 293-8. PMID: 9989214
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kasugamycin Hydrochloride Monohydrate, 1 g | sc-200104 | 1 g | $70.00 |