Kassinin (CAS 63968-82-1)

Kassinin, a tetracosapeptide from the tachykinin family, was initially isolated from the skin of the African frog *Kassina senegalensis*. Like its relatives in the tachykinin peptide group, kassinin engages with neurokinin receptors, particularly the NK1 subtype, which are prevalent across various nervous system tissues. This interaction triggers a series of biochemical events starting with the activation of phospholipase C, leading to the increased production of inositol triphosphate and diacylglycerol. These molecules enhance intracellular calcium levels, facilitating neurotransmitter release and influencing pain pathways and inflammatory responses. Kassinin′s role in research has been pivotal in dissecting the functionalities of tachykinin receptors, offering insights into neurophysiological and neuropharmacological processes. By studying kassinin′s effects, researchers have deepened their understanding of pain modulation, neurotransmission, and the mechanisms underpinning inflammation, contributing significantly to the field of neurobiology without any direct clinical or therapeutic application. This foundational research provides valuable knowledge that could inform future studies exploring the potential of targeting neurokinin pathways in various neurological conditions.