Molecular structure of Kaempferol, CAS Number: 520-18-3
Kaempferol (CAS 520-18-3)
See product citations (11)
Alternate Names:
3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Robigenin
Application:
Kaempferol is an inhibitor of Fatty Acid Synthase, COX-1 activity, and Topo I
CAS Number:
520-18-3
Purity:
≥98%
Molecular Weight:
286.24
Molecular Formula:
C15H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kaempferol is a naturally occurring flavonoid shown to act as a potent reversible inhibitor of Fatty Acid Synthase. Flavonoids have radical scavenging activity. Studies demonstrate that Kaempferol induces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity. Additionally, it may act to have a neuroprotective effect and represses the advancement of allergic inflammation mediated by IgE in difference cell models. A study which compared the CYP246 activity of Galangin (sc-235240), quercetin (sc-206089), and Kaempferol revealed that Kaempferol was the least potent flavanoid, with quercetin having the highest potency. Kaempferol acts as an inhibitor of Cox-1 activity (IC50 = 180 muM) and inhibits Topo I catalyzed DNA religation in HL-60 cells. It is also an inhibitor of MAO.
Kaempferol (CAS 520-18-3) References
- Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance. | Li, BH. and Tian, WX. 2003. J Enzyme Inhib Med Chem. 18: 349-56. PMID: 14567550
- Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? | Lupu, R. and Menendez, JA. 2006. Curr Pharm Biotechnol. 7: 483-93. PMID: 17168665
- Protective effects of kaempferol (3,4',5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice. | Kim, JK., et al. 2010. Biosci Biotechnol Biochem. 74: 397-401. PMID: 20139605
- Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells. | Lee, EJ., et al. 2010. Inflamm Res. 59: 847-54. PMID: 20383790
- In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity. | Tiong, KH., et al. 2010. Xenobiotica. 40: 458-66. PMID: 20402563
- Kaempferol: A Key Emphasis to Its Anticancer Potential. | Imran, M., et al. 2019. Molecules. 24: PMID: 31248102
- The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies. | Wong, SK., et al. 2019. Drug Des Devel Ther. 13: 3497-3514. PMID: 31631974
- Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing. | Alam, W., et al. 2020. Molecules. 25: PMID: 32906577
- Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol. | Rahul,. and Siddique, YH. 2021. CNS Neurol Disord Drug Targets. 20: 327-342. PMID: 33511932
- Kaempferol attenuates diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells. | Jin, Y., et al. 2021. Food Funct. 12: 6889-6899. PMID: 34338265
- Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism. | Berger, A., et al. 2022. Curr Opin Plant Biol. 66: 102165. PMID: 35026487
- Kaempferol ameliorates in-vitro and in-vivo postovulatory oocyte ageing in mice. | Zeng, ZC., et al. 2022. Reprod Biomed Online. 45: 1065-1083. PMID: 36280424
- Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. | Periferakis, A., et al. 2022. Int J Mol Sci. 23: PMID: 36499380
- Structure-antioxidant activity relationships of flavonoids and phenolic acids. | Rice-Evans, CA., et al. 1996. Free Radic Biol Med. 20: 933-56. PMID: 8743980
Inhibitor of:
α4-crystallin, β-1,3-Gal-T4, β-defensin 129, β-glucuronidase, μ-crystallin, 15-LO, Ah Receptor, Angptl4, ANT1, BC049352, beta-glucosidase, Brn-3a, C14orf148, C15orf41, C17orf96, C20orf96, CaMK2N2, CCDC141, CCL16, CCL28, CDY1, Chemokine Receptor D6, CRISP-1, CTAP-III, CTLA-2β, CTLA-4, CYLC1, DDT, Dlx-6, DUSP4, EMILIN-5, Ep-CAM, ephrin-B3, Factor H, Fatty Acid Synthase, FLTR3, FN3K, FOXD4L1-6, FOXE2, Gα gust, GAGE10, GAL3ST3, Galactose Mutarotase, galectin-3, GILZ, Glut11, GRK 5, GRO, HS6ST2, IER3IP1, IgE Chain C, IL-10Rα, IL-TIFb, Integrin β3, Ivl, KRTAP13, L-Glycerol-3-Phosphate Oxidase, Lce1m, LCE3A, LCE3B, Lipocalin-12, MAdCAM, MAO, MBP, MDA5, Measles NP, MOSC2, MOV10, MYLK, NCoA-3, Nkx-2.8, NNT-1/BSF-3, Nucling, Olfr810, Parkin, PATE3, PC1, PDDC1, PEA3, PEBP-4, PGP-I, PI 3-kinase, Pim-2, PON3, Psg19, Psg21, Psg23, Psg25, Psg26, Psg27, Psg28, PSGL-1, RAO, RAP1, RFT1, RUNX2, SDR-O, SerpinB12, SETMAR, sFlt-1, SGLT-3, Slfn1, SNAI 1, SOX (SRY-box transcription factor), Sox-10, Sox-9, SOX15, Speedy C, SPRR2, Sulf-1, SULT1A3, SULT1C1, SULT2A5, SULT2B1, SULT2B10, SULT5A1, SV40 T Ag, T2R20, T2R29, Tas2r102, Tas2r114, Tas2r140, Tas2r143, Tenr, TEX24, Thrombospondin 2, Tpbpb, Tryptase ε, TSG-6, UBA52, UGT2A1, UGT2B37, UGT2B5, V1RC24, V1RC25, V1RC32, V1rc5, V1RF5, vanin-3, Vgl-3, WDR38, XKR8, Xlr3c, Xlr4c, Xlr5c, ZNF217, and ZNF737.Activator of:
β-defensin 11, β-Glucoronidase, 17-β Estradiol 6, 4930444G20Rik, AATK, ABHD6, ADF, AF9, APPL1, ARGFX, BBS9, Bclp2, Bikunin, BMP-7, c-Erb-A β-1, C11orf59, C1orf129, C1orf158_1700012P22Rik, C1orf175, C1orf227, C1orf53, C3orf18, C5, C5L2, CD40L, Centrin-2, CHS, COL11A2, creatine kinase-M, Cyp4f16, DALRD3, Dectin-2, Dlx-5, DNA pol ε, DNA pol ε 4, DNAH2, DnaJB3, DnaJC28, DnaJC5γ, DNAL4, Dynactin 6, EG243302, ER beta, FAM3D, FBXW22, Gelsolin, Glut5, Glut7, GPN2, GPR156, GSDMC4, H2-M10.5, H2-Q8, Helicobacter pylori HSP, HHLA2, HMG-17, HSPC016, HTR3C, Humanin, IGSF10, IKAP, IP-10, IQCF1, IRS-1, Jaz, KIAA0090, KIAA1324L, Klkb1, KRTAP16-7, Lipocalin-5, LOC100039269, LOC100039631, LOC100039830, LOC100040130, LOC100040307, LOC100040585, LOC100040722, LOC100040923, LOC100041019, LOC100041119, LOC100041224, LOC100041253, LOC100041281, LOC100041317, LOC284023, LOC441792, LOC644248, LOC644264, LOC646567, LOXL1, LRRN1, LTBP-3, MAGE-B1, MBIP, MCTS1, Measles M, MEDA-4, MEK-4, NAB1, NALP9A, NBPF6, NPC1L1, Nrarp, Oas1f, OAT6, OR10K1, OR10Z1, OR13G1, OR2C3, OR2L8, OR2M5, OR2T29, OR2W3, OR5BU1, OR5H14, OR5H6, OR6Y1, OTTMUSG00000016414, OTTMUSG00000019784, P2P-R, PARP-2, PDGFR-α, Pellino 2, PGBD2, PIASx, PRAT4A, PRX I, RAG1AP1, Rb, RBM10, reaper, RGPD7, RTP3, S19BP, SAA4, SAPS1, SerpinA3j, Sin3, SIRT1, SIRT5, SLC22A9, SLC26A9, Spaca6, Spastin, SPOP, Sprr2a2, SR-4, SULT2A1, SULT2A5, TAB3, TAG, TBC1D8B, tcag7.873, TCR C β, TEDDM1, TFIIH p44, TGIF2LX2, TM4SF19, TMEM44, TMPRSS11D, TMPRSS2, TRIM30C, TRNP-1, USP11, USP29, VPS33B, VSIG8, WDR38, WDR40A, XPC, ZCWPW2, ZNF189, ZNF222, ZNF434, ZNF501, ZNF576, ZNF642, ZNF659, and ZNF687.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kaempferol, 25 mg | sc-202679 | 25 mg | $97.00 | |||
Kaempferol, 100 mg | sc-202679A | 100 mg | $212.00 | |||
Kaempferol, 1 g | sc-202679B | 1 g | $500.00 |