K-cadherin Antibody (4A10): sc-71463

K-cadherin Antibody (4A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects K-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-K-cadherin antibody (4A10) is available in a non-conjugated form, providing flexibility for various experimental needs. K-cadherin, also known as cadherin-6, plays a crucial role in cell adhesion, essential for maintaining tissue integrity and facilitating proper morphogenesis during development. K-cadherin is primarily located at the cell membrane, where adherens junctions form to connect adjacent cells, contributing to tissue structural stability. K-cadherin′s membrane location helps establish and maintain tissue architecture while influencing signaling pathways that regulate cell behavior, including proliferation and differentiation. K-cadherin interacts with cytoplasmic proteins such as β-catenin, vital for transducing signals that affect cellular functions. These interactions underscore K-cadherin′s significance in both normal physiological processes and pathological conditions, making K-cadherin (4A10) antibody an invaluable tool for researchers studying cell adhesion and its implications in health and disease.

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K-cadherin Antibody (4A10) References:

1. Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.  |  Shimoyama, Y., et al. 1999. J Biol Chem. 274: 11987-94. PMID: 10207020
2. Detection of cadherin-6 mRNA by nested RT-PCR as a potential marker for circulating cancer cells in renal cell carcinoma.  |  Shimazui, T., et al. 2003. Int J Oncol. 23: 1049-54. PMID: 12963985
3. Cadherin-6: a new prognostic marker for renal cell carcinoma.  |  Paul, R., et al. 2004. J Urol. 171: 97-101. PMID: 14665853
4. The level of cadherin-6 mRNA in peripheral blood is associated with the site of metastasis and with the subsequent occurrence of metastases in renal cell carcinoma.  |  Shimazui, T., et al. 2004. Cancer. 101: 963-8. PMID: 15329904
5. Cadherin-6 gene regulatory patterns in the postnatal mouse brain.  |  Inoue, YU., et al. 2008. Mol Cell Neurosci. 39: 95-104. PMID: 18617008
6. Concomitant high expression of BRAFV600E, P-cadherin and cadherin 6 is associated with High TNM stage and lymph node metastasis in conventional papillary thyroid carcinoma.  |  Zhao, L., et al. 2016. Clin Endocrinol (Oxf). 84: 748-55. PMID: 26285159
7. Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy.  |  Gugnoni, M., et al. 2017. Oncogene. 36: 667-677. PMID: 27375021
8. Construction and Characterization of Cadherin 6 (CDH6)-Targeting Chimeric Antigen Receptor (CAR) Modified T Cells.  |  Pang, L., et al. 2022. J Environ Pathol Toxicol Oncol. 41: 55-71. PMID: 35378004
9. Isolation of complementary DNA encoding K-cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma.  |  Xiang, YY., et al. 1994. Cancer Res. 54: 3034-41. PMID: 8187093
10. Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma.  |  Shimazui, T., et al. 1998. Clin Cancer Res. 4: 2419-24. PMID: 9796973

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-K-cadherin Antibody (4A10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-K-cadherin Antibody (4A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

K-cadherin Antibody (4A10) Specifications

Alternate Product Name: CDH6

Product Clone Name: 4A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: K-cadherin

Epitope Species: human

Product Reactivity/Detection: K-cadherin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for K-cadherin Antibody (4A10): N/A