K-562 + TNFα Cell Lysate: sc-24723

K-562 + TNFα Cell Lysate is prepared from K-562 cells, a human chronic myelogenous leukemia cell line, treated with tumor necrosis factor-alpha (TNFα), a cytokine involved in systemic inflammation and a mediator of immune responses. This cell line is particularly useful for studying hematopoietic and leukemic cell behavior under the influence of cytokines like TNFα. When exposed to TNFα, K-562 cells undergo various signaling cascades that modulate gene expression, cell survival, apoptosis, and differentiation. The lysate derived from these treated cells offers a rich mixture of proteins, RNA, and other cellular components, capturing the dynamic cellular states induced by TNFα stimulation. Researchers utilize this lysate to investigate the effects of TNFα on leukemic cells, particularly focusing on how inflammatory cytokines influence cancer cell survival, proliferation, and death. Additionally, it serves as a valuable tool for probing the intracellular signaling pathways activated by TNFα, including NF-κB and apoptosis-related pathways. By analyzing K-562 + TNFα Cell Lysate, scientists can gain insights into the complex interactions between cytokines and leukemia cells, furthering our understanding of the cellular mechanisms that underpin inflammation and immune responses in cancerous contexts. This lysate is instrumental in advancing research in cellular and molecular immunology, providing key insights that help delineate the role of cytokines in disease physiology.