JYL1421 (CAS 401907-26-4)
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JYL1421 is a chemical that functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It acts by binding to the active site of the enzyme, preventing its normal function and disrupting the downstream signaling cascade. This disruption ultimately leads to the inhibition of cell proliferation and survival. JYL1421 may modulate the expression of certain genes involved in cell cycle regulation, further contributing to its inhibitory effects on cellular growth. Its mode of action involves interfering with the phosphorylation of key proteins involved in cell signaling, thereby disrupting the transmission of signals that promote cell proliferation. JYL1421 plays a role in elucidating the molecular mechanisms underlying cell growth and survival, providing insights in the field of cellular biology and signaling pathways.
JYL1421 (CAS 401907-26-4) References
- Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. | Jakab, B., et al. 2005. Eur J Pharmacol. 517: 35-44. PMID: 15978575
- The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. | Gavva, NR., et al. 2007. J Neurosci. 27: 3366-74. PMID: 17392452
- The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis. | Miranda, A., et al. 2007. Neuroscience. 148: 1021-32. PMID: 17719181
- Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats. | Peles, S., et al. 2009. Neuroscience. 161: 515-25. PMID: 19324074
- Involvement of the transient receptor potential vanilloid 1 (TRPV1) in the development of acute visceral hyperalgesia during colorectal distension in rats. | Ravnefjord, A., et al. 2009. Eur J Pharmacol. 611: 85-91. PMID: 19344705
- Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder. | Cefalu, JS., et al. 2009. J Urol. 182: 776-85. PMID: 19539322
- TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells. | Pan, Z., et al. 2011. Invest Ophthalmol Vis Sci. 52: 485-93. PMID: 20739465
- TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. | Blumberg, PM., et al. 2011. Curr Top Med Chem. 11: 2151-8. PMID: 21671879
- The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation. | Papakosta, M., et al. 2011. J Biol Chem. 286: 39663-72. PMID: 21911503
- TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. | Garami, A., et al. 2018. Acta Physiol (Oxf). 223: e13038. PMID: 29352512
- Differences in the effects of TRPV1 antagonists on energy metabolism in mice. | Hai, J., et al. 2018. Biomed Res. 39: 279-286. PMID: 30531157
- Transient Receptor Potential Channels and Inflammatory Bowel Disease. | Chen, Y., et al. 2020. Front Immunol. 11: 180. PMID: 32153564
- Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain. | Rahman, MM., et al. 2022. Int J Mol Sci. 23: PMID: 36555495
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JYL1421, 500 µg | sc-473088 | 500 µg | $46.00 | |||
JYL1421, 1 mg | sc-473088A | 1 mg | $82.00 |