Molecular structure of JYL-79
JYL-79
Alternate Names:
2-(3,4-Dimethylbenzyl)-3-{[(4-hydroxy-3-methoxy-benzyl)amino]carbothioyl}propyl pivalate, Vanilloid Receptor Agonist 23
Application:
JYL-79 is a VR1 agonist
Purity:
≥98%
Molecular Weight:
472.64
Molecular Formula:
C26H36N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
JYL-79 is a potent vanilloid receptor (VR1) agonist (Ki = 19 nM), structurally based on resiniferatoxin (RTX). JYL-79 is more potent than capsaicin (sc-3577).
JYL-79 References
- N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. | Lee, J., et al. 2001. Bioorg Med Chem. 9: 19-32. PMID: 11197340
- Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. | Lee, J., et al. 2002. Bioorg Med Chem. 10: 1171-9. PMID: 11836128
- Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. | Tóth, A., et al. 2005. Life Sci. 76: 2921-32. PMID: 15820503
- Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1. | Czikora, Á., et al. 2012. Br J Pharmacol. 165: 1801-1812. PMID: 21883148
- Effects of in-vitro modulation of TRPV1 activity on immune response of mice bearing metastatic breast carcinoma: Enhanced inflammatory response may hinder therapeutic potentials of TRPV1 agonists. | Erin, N. and Akman, M. 2021. Life Sci. 287: 120115. PMID: 34740578
Activator of:
VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JYL-79, 1 mg | sc-221785 | 1 mg | $41.00 | |||
JYL-79, 5 mg | sc-221785A | 5 mg | $218.00 |