Molecular structure of JYL-273, CAS Number: 289902-71-2
JYL-273 (CAS 289902-71-2)
Application:
JYL-273 is a potent VR1 (TRPV1) agonist with reported high potency over capsaicin
CAS Number:
289902-71-2
Molecular Weight:
500.7
Molecular Formula:
C28H40N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
JYL-273 is a potent VR1 (TRPV1) agonist (Ki=11nM). About 500-fold more potent than capsaicin . RTX binding affinity (Ki = 6.35 nM), agonism (calcium influx; EC50=2.83nM).
JYL-273 (CAS 289902-71-2) References
- N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. | Lee, J., et al. 2001. Bioorg Med Chem. 9: 19-32. PMID: 11197340
- Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. | Lee, J., et al. 2002. Bioorg Med Chem. 10: 1171-9. PMID: 11836128
- Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1. | Czikora, Á., et al. 2012. Br J Pharmacol. 165: 1801-1812. PMID: 21883148
Activator of:
VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JYL-273, 1 mg | sc-202678 | 1 mg | $48.00 | |||
JYL-273, 5 mg | sc-202678A | 5 mg | $192.00 |