JYL-273 is a potent TRPV1 agonist (Ki=11nM). About 500-fold more potent than capsaicin . RTX binding affinity (Ki = 6.35 nM), agonism (calcium influx; EC50=2.83nM).
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 9, 19 (2001) Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 10, 1171 (2002)
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