JYL-273 CAS: 289902-71-2
MF: C28H40N2O4S
MW: 500.7
A potent TRPV1 agonist with reported high potency over capsaicin.

JYL-273 (CAS 289902-71-2)

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Application: JYL-273 is a potent VR1 (TRPV1) agonist with reported high potency over capsaicin
CAS Number: 289902-71-2
Molecular Weight: 500.7
Molecular Formula: C28H40N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

JYL-273 is a potent TRPV1 agonist (Ki=11nM). About 500-fold more potent than capsaicin . RTX binding affinity (Ki = 6.35 nM), agonism (calcium influx; EC50=2.83nM).


References

N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 9, 19 (2001) Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 10, 1171 (2002)

Physical State :
Solid
Solubility :
Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9806014
SMILES :
CC(C)(C)C1=CC=C(C=C1)CC(CNC(=S)NCC2=CC(=C(C=C2)O)OC)COC(=O)C(C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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