JX-401 CAS: 349087-34-9
MF: C21H25NO2S
MW: 355.49
A potent non-cytotoxic cell membrane permeable p38α inhibitor.

JX-401 (CAS 349087-34-9)

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Synonym: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Application: A potent non-cytotoxic cell membrane permeable p38α inhibitor
CAS Number: 349087-34-9
Purity: ≥95%
Molecular Weight: 355.49
Molecular Formula: C21H25NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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JX-401 is a potent non-cytotoxic cell membrane permeable p38α inhibitor that acts by reversibly binding MAPK p38α. Yet it is non functional against p38γ.


References

1. Friedmann, Y., et al. 2006. Mol. Pharmacol. 70: 1395-1405. PMID: 16847144

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/mL), and ethanol (10 mg/mL).
Storage :
Store at -20° C
Melting Point :
196.00° C (Predicted)
Boiling Point :
~537.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (lit.)
IC50 :
p38α: IC50 = 32 nM; p38γ: IC50 = 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1126109
MDL Number :
MFCD02038777
SMILES :
COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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Is this product IATA regulated?

Asked by: hawkeye11
Thank you for your question. The compound, sc-200687, is not an IATA regulated product. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-31
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