Molecular structure of JTE 907, CAS Number: 282089-49-0
JTE 907 (CAS 282089-49-0)
Alternate Names:
N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-Quinolinecarboxamide
Application:
JTE 907 is a highly selective CB2 receptor inverse agonist
CAS Number:
282089-49-0
Molecular Weight:
438.48
Molecular Formula:
C24H26N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist. It binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). It increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2. Potent and selective ligands for CB2 receptors have anti-inflammatory properties.
JTE 907 (CAS 282089-49-0) References
- In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. | Iwamura, H., et al. 2001. J Pharmacol Exp Ther. 296: 420-5. PMID: 11160626
- Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. | Ueda, Y., et al. 2005. Eur J Pharmacol. 520: 164-71. PMID: 16153638
- Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists. | Raitio, KH., et al. 2006. J Med Chem. 49: 2022-7. PMID: 16539390
- The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. | Maekawa, T., et al. 2006. Eur J Pharmacol. 542: 179-83. PMID: 16824511
- Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice. | Ueda, Y., et al. 2007. Life Sci. 80: 414-9. PMID: 17055000
- The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. | Smid, SD., et al. 2007. Eur J Pharmacol. 575: 168-76. PMID: 17706636
- Functional CB2 type cannabinoid receptors at CNS synapses. | Morgan, NH., et al. 2009. Neuropharmacology. 57: 356-68. PMID: 19616018
- Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907. | González-Muniesa, P., et al. 2010. Horm Metab Res. 42: 710-7. PMID: 20603779
- Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. | Franklin, JM., et al. 2013. Pharmacol Res. 68: 46-58. PMID: 23174265
- Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. | Harvey, BS., et al. 2013. Cytokine. 63: 209-17. PMID: 23706402
- Presynaptic cannabinoid CB2 receptors modulate [3 H]-Glutamate release at subthalamo-nigral terminals of the rat. | Sánchez-Zavaleta, R., et al. 2018. Synapse. 72: e22061. PMID: 30022523
- Direct Stimulatory Effects of the CB2 Ligand JTE 907 in Human and Mouse Islets. | Ruz-Maldonado, I., et al. 2021. Cells. 10: PMID: 33809893
- Cannabinoid receptor 2 (Cb2r) mediates cannabinol (CBN) induced developmental defects in zebrafish. | Amin, MR., et al. 2022. Sci Rep. 12: 20251. PMID: 36424484
Inhibitor of:
CB2, CBG, CBS, CCL27b, CNR2, GPR18, Olfr1274, OR4K15, Vmn1r152, Vmn2r63, and Vmn2r95.Activator of:
CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JTE 907, 10 mg | sc-203616 | 10 mg | $289.00 | |||
JTE 907, 50 mg | sc-203616A | 50 mg | $1122.00 |