Molecular structure of JTC 801, CAS Number: 244218-51-7
JTC 801 (CAS 244218-51-7)
Alternate Names:
N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride
Application:
JTC 801 is a high affinity, selective NOP (KOR-3) receptor antagonist
CAS Number:
244218-51-7
Molecular Weight:
447.96
Molecular Formula:
C26H25N3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
High affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.
JTC 801 (CAS 244218-51-7) References
- 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. | Shinkai, H., et al. 2000. J Med Chem. 43: 4667-77. PMID: 11101358
- Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. | Yamada, H., et al. 2002. Br J Pharmacol. 135: 323-32. PMID: 11815367
- Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model. | Suyama, H., et al. 2003. Neurosci Lett. 351: 133-6. PMID: 14623124
- Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. | Tamai, H., et al. 2005. Eur J Pharmacol. 510: 223-8. PMID: 15763246
- JTC-801 exerts anti-proliferative effects in human osteosarcoma cells by inducing apoptosis. | Zheng, CJ., et al. 2018. J Recept Signal Transduct Res. 38: 133-140. PMID: 29447541
- JTC-801 inhibits the proliferation and metastasis of ovarian cancer cell SKOV3 through inhibition of the PI3K - AKT signaling pathway. | Li, JX., et al. 2018. Pharmazie. 73: 283-287. PMID: 29724295
- JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways. | Li, J. and Huang, F. 2018. Med Sci (Paris). 34 Focus issue F1: 8-14. PMID: 30403168
- JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway. | Zhao, B. and Hu, T. 2019. Oncol Lett. 17: 1939-1945. PMID: 30675258
- JTC-801 alleviates mechanical allodynia in paclitaxel-induced neuropathic pain through the PI3K/Akt pathway. | Huang, J., et al. 2020. Eur J Pharmacol. 883: 173306. PMID: 32603693
- Synergistic suppressive effects on triple-negative breast cancer by the combination of JTC-801 and sodium oxamate. | Wang, CY., et al. 2023. Am J Cancer Res. 13: 4661-4677. PMID: 37970352
Inhibitor of:
KOR-3, and MOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JTC 801, 10 mg | sc-203614 | 10 mg | $128.00 | |||
JTC 801, 50 mg | sc-203614A | 50 mg | $571.00 |