Molecular structure of Josamycin, CAS Number: 16846-24-5
Josamycin (CAS 16846-24-5)
Application:
Josamycin is a macrolide antibiotic effective against a variety of pathogens
CAS Number:
16846-24-5
Molecular Weight:
827.99
Molecular Formula:
C42H69NO15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Josamycin is a member of the leucomycin group of macrolide antibiotics with a 16 member lactone ring produced by Streptomyces kitasatoensis and Streptomyces narbonensis var. josamyceticus. The compounds main use has been against gram-positive bacteria. The compound has been documented to function through direct inhibition of peptidyltransferase reaction as well as drop off of peptidyl-tRNA translation from ribosomes. The strength action was observed to be dependent on peptide length, no more than 3 amino acids, and composition of amino acids, fMet-Phe-tRNA or fMet-Val-tRNA. Kinetic studies demonstrated that Josamycin binds directly to the ribosome.
Josamycin (CAS 16846-24-5) References
- A case-control teratological study of spiramycin, roxithromycin, oleandomycin and josamycin. | Czeizel, AE., et al. 2000. Acta Obstet Gynecol Scand. 79: 234-7. PMID: 10716307
- Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo. | Wang, L., et al. 2000. Clin Exp Pharmacol Physiol. 27: 587-93. PMID: 10901387
- A chronic toxicity study of josamycin in F344 rats. | Kasahara, K., et al. 2002. Food Chem Toxicol. 40: 1017-22. PMID: 12065224
- Kinetics of macrolide action: the josamycin and erythromycin cases. | Lovmar, M., et al. 2004. J Biol Chem. 279: 53506-15. PMID: 15385552
- Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin. | Lovmar, M., et al. 2009. Biochimie. 91: 989-95. PMID: 19463886
- Characterization of impurities in josamycin using dual liquid chromatography combined with mass spectrometry. | Van den Bossche, L., et al. 2013. J Pharm Biomed Anal. 73: 66-76. PMID: 22326844
- Synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin. | Zhao, ZH., et al. 2017. J Asian Nat Prod Res. 19: 358-387. PMID: 28276768
- Topical Application of Josamycin Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. | Matsui, K., et al. 2017. J Pharm Pharm Sci. 20: 38-47. PMID: 28459659
- Josamycin suppresses Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages. | Choi, EY., et al. 2018. Biomed Pharmacother. 105: 498-505. PMID: 29883945
- Characterization of a new component and impurities in josamycin by trap-free two-dimensional liquid chromatography coupled to ion trap time-of-flight mass spectrometry. | Liu, G., et al. 2019. Rapid Commun Mass Spectrom. 33: 1058-1066. PMID: 30907019
- Analysis of josamycin in three kinds of feed using ultra high performance liquid chromatography with tandem mass spectrometry. | Han, J., et al. 2019. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36: 1302-1313. PMID: 31241416
- Universal response method for the quantitative analysis of multi-components in josamycin and midecamycin using liquid chromatography coupled with charged aerosol detector. | Liu, G., et al. 2021. J Pharm Biomed Anal. 192: 113679. PMID: 33120309
- Effects of Josamycin on Scratching Behavior in NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions. | Matsui, K., et al. 2021. Biol Pharm Bull. 44: 798-803. PMID: 34078811
- A new antibiotic, josamyicn. I. Isolation and physico-chemical characteristics. | Osono, T., et al. 1967. J Antibiot (Tokyo). 20: 174-80. PMID: 6072798
- A comparison of josamycin with macrolides and related antibiotics on isolated rat atria. | Tamargo, J., et al. 1982. Eur J Pharmacol. 80: 285-93. PMID: 7106186
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Josamycin, 50 mg | sc-351855A | 50 mg | $67.00 | |||
Josamycin, 200 mg | sc-351855 | 200 mg | $169.00 | |||
Josamycin, 2.5 g | sc-351855B | 2.5 g | $1154.00 |