Molecular structure of JNK Inhibitor XI, CAS Number: 2207-44-5
JNK Inhibitor XI (CAS 2207-44-5)
Alternate Names:
BI-87G3, 2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole
Application:
JNK Inhibitor XI is a JNK1 and JNK2 inhibitor
CAS Number:
2207-44-5
Purity:
≥95%
Molecular Weight:
295.4
Molecular Formula:
C10H5N3O2S3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
JNK Inhibitor XI is a cell-permeable benzothiazole compound that inhibits JNK kinase activity (IC50 = 1.8 µM against ATF2 phosphorylation by JNK1) by competing with substrate binding (IC50 = 0.16 µM against pepJIP1 binding to JNK2), while exhibiting much reduced activity toward two other kinases (IC50 >100 µM against p38α and Akt) and two other proteases (IC50 >50 and >100 µM, respectively, against furin and LF). Shown to effectively block cellular c-Jun phosphorylation upon TNF-α stimulation even in HeLa cultures with overexpressed c-Jun substrate (IC50 = 15 µM) and display favorable stability in rat microsome (t1/2 = 70 min) as well as plasma (80% remaining after 60 min) stability assays at 37°C.
Inhibitor of:
JNK1, JNK2, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNK Inhibitor XI, 10 mg | sc-364743 | 10 mg | $150.00 |