JNK Inhibitor IX (CAS 312917-14-9)
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The thienylnaphthamide compound c-Jun N-terminal kinase (JNK) inhibitor IX is a selective and potent inhibitor of the ATP binding site of JNK2 and JNK3. JNK1, p38α and other kinases are effected slightly or not at all when JNK2 and JNK3 are inhibited by the JNK inhibitor IX. In comparison to SP600125 (sc-200635), the inhibitor of JNK, JNK inhibitor IX is more selective between JNK1 and JNK3.The JNK pathway plays important roles in various cellular processes and is activated when cells are exposed to proinflammatory cytokines, environmental stress and different anticancer drugs. Research shows that JNK1, JNK2, and JNK3 are associated in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.
JNK Inhibitor IX (CAS 312917-14-9) References
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- Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. | Rudolf, E. and Cervinka, M. 2009. Toxicol Lett. 188: 236-42. PMID: 19406221
- JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells. | Yan, F., et al. 2010. Hepatobiliary Pancreat Dis Int. 9: 287-95. PMID: 20525557
- JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. | Liu, J., et al. 2012. Toxicol Sci. 129: 363-71. PMID: 22696236
- Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells. | Jang, WY., et al. 2014. Biochem Biophys Res Commun. 452: 845-51. PMID: 25218503
- Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells. | Zhou, C., et al. 2016. Tumour Biol. 37: 3135-44. PMID: 26427664
- ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration. | Santabárbara-Ruiz, P., et al. 2015. PLoS Genet. 11: e1005595. PMID: 26496642
- C-Jun N-terminal kinase signalling pathway in response to cisplatin. | Yan, D., et al. 2016. J Cell Mol Med. 20: 2013-2019. PMID: 27374471
- The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons. | Guha, I., et al. 2016. Neurobiol Aging. 46: 138-48. PMID: 27490965
- JNK inhibitor IX restrains pancreatic cancer through p53 and p21. | Shi, J., et al. 2022. Front Oncol. 12: 1006131. PMID: 36568248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNK Inhibitor IX, 5 mg | sc-202671 | 5 mg | $226.00 |