Molecular structure of JNK Inhibitor II, negative control, CAS Number: 54642-23-8
JNK Inhibitor II, negative control (CAS 54642-23-8)
Application:
JNK Inhibitor II, negative control is a negative control for JNK Inhibitor II
CAS Number:
54642-23-8
Molecular Weight:
234.25
Molecular Formula:
C15H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JNK Inhibitor II, Negative Control is useful as a negative control for JNK Inhibitor II (sc-200635) as it only inhibits JNK2 and JNK3 at much higher concentrations (IC50 = 18 μM and 24 μM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
JNK Inhibitor II, negative control (CAS 54642-23-8) References
- SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. | Bennett, BL., et al. 2001. Proc Natl Acad Sci U S A. 98: 13681-6. PMID: 11717429
- An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. | Shin, M., et al. 2002. Biochim Biophys Acta. 1589: 311-6. PMID: 12031798
- Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. | Thiel, A., et al. 2006. J Biol Chem. 281: 4564-9. PMID: 16371352
- C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. | Brust, TB., et al. 2007. Neuropharmacology. 53: 906-17. PMID: 17967469
- Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway. | Haga, A., et al. 2008. FEBS Lett. 582: 1877-82. PMID: 18485900
- Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells. | Haga, A., et al. 2009. Cancer Invest. 27: 384-90. PMID: 19212832
- Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. | Thompson, WL. and Van Eldik, LJ. 2009. Brain Res. 1287: 47-57. PMID: 19577550
- JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells. | Donnellan, F., et al. 2010. Am J Physiol Gastrointest Liver Physiol. 298: G37-44. PMID: 19875701
- Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulation of GluA2 and GluA1 subunits by p38 MAPK and JNK. | Chen, Z., et al. 2014. J Neurosci. 34: 9621-43. PMID: 25031403
- Suppression of delayed rectifier K+ channels by gentamicin induces membrane hyperexcitability through JNK and PKA signaling pathways in vestibular ganglion neurons. | Zhang, Y., et al. 2021. Biomed Pharmacother. 135: 111185. PMID: 33422932
Inhibitor of:
JNK2, JNK3, Ser/Thr Protein Kinase, and YSK4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNK Inhibitor II, negative control, 1 mg | sc-221781 | 1 mg | $78.00 |