Molecular structure of JNJ 303, CAS Number: 878489-28-2
JNJ 303 (CAS 878489-28-2)
Alternate Names:
2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
Application:
JNJ 303 is a potent IKS blocker that does not display effects on other cardiac channels
CAS Number:
878489-28-2
Purity:
≥98%
Molecular Weight:
440.98
Molecular Formula:
C21H29ClN2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JNJ 303 is a specific compound known for its role as a potent and selective blocker of the potassium channel subfamily KQT member 2 (Kv7.2), which is part of a group of voltage-gated potassium channels important for regulating the excitability of nerve cells. By inhibiting these channels, JNJ 303 can affect the electrical activity of cells, particularly in the nervous system. JNJ 303 is used to study the role of Kv7.2 channels in cellular models, providing insights into the basic mechanisms of neuronal signaling and the potential for targeting these channels.
JNJ 303 (CAS 878489-28-2) References
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- Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment. | Zhang, X., et al. 2016. J Pharmacol Toxicol Methods. 81: 201-16. PMID: 27282640
- Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model. | Lu, HR., et al. 2016. J Pharmacol Toxicol Methods. 81: 151-60. PMID: 27374776
- The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. | Kuusela, J., et al. 2016. Stem Cell Rev Rep. 12: 698-707. PMID: 27646833
- KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. | Wrobel, E., et al. 2016. Nat Commun. 7: 12795. PMID: 27731317
- β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle. | Kang, C., et al. 2017. Sci Rep. 7: 15922. PMID: 29162896
- Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. | Björk, S., et al. 2017. Front Physiol. 8: 884. PMID: 29163220
- Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. | Millard, D., et al. 2018. Toxicol Sci. 164: 550-562. PMID: 29718449
- Electrophysiological characterization of drug response in hsc-derived cardiomyocytes using voltage-sensitive optical platforms. | Pfeiffer-Kaushik, ER., et al. 2019. J Pharmacol Toxicol Methods. 99: 106612. PMID: 31319140
- Role of somatic cell sources in the maturation degree of human induced pluripotent stem cell-derived cardiomyocytes. | Pianezzi, E., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118538. PMID: 31472168
- NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis. | Ronchi, C., et al. 2021. Cardiovasc Res. 117: 472-483. PMID: 32061134
- IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog. | van Bavel, JJA., et al. 2022. Eur J Pharmacol. 932: 175218. PMID: 36007604
- MS07.2 Sex Difference of Repolarization Reserve On Drug-induced QT Prolongation and Arrhythmias | F. Wei ∗ 1 2, C. Cai 1, L. Pang 1. 2018. Global Heart. 13: 382.
Inhibitor of:
KCNE4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ 303, 10 mg | sc-361217 | 10 mg | $412.00 | |||
JNJ 303, 50 mg | sc-361217A | 50 mg | $1686.00 |