Molecular structure of JNJ 28871063 hydrochloride, CAS Number: 944341-54-2
JNJ 28871063 hydrochloride (CAS 944341-54-2)
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Alternate Names:
5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
CAS Number:
944341-54-2
Purity:
>97%
Molecular Weight:
519.42
Molecular Formula:
C24H27CIN6O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM). Inhibits growth of human tumor xenografts in vivo. Orally active and brain penetrant.
JNJ 28871063 hydrochloride (CAS 944341-54-2) References
Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271. Emanuel et al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338. Guessous et al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217 577.Inhibitor of:
EGFR, ErbB-4, and Neu.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ 28871063 hydrochloride, 10 mg | sc-204025 | 10 mg | $215.00 | |||
JNJ 28871063 hydrochloride, 50 mg | sc-204025A | 50 mg | $880.00 |