Molecular structure of JNJ 17203212, CAS Number: 821768-06-3
JNJ 17203212 (CAS 821768-06-3)
Alternate Names:
4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE
Application:
JNJ 17203212 is a high affinity TRPV1 receptor antagonist
CAS Number:
821768-06-3
Purity:
≥98%
Molecular Weight:
419.33
Molecular Formula:
C17H15F6N5O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JJNJ 17203212 is a high affinity transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. TRPV1 is a capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. The compound has been used to investigate TRPV1 in rodent and guinea pig sensory reflexes. Research indicates that JNJ 17203212 elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity.
JNJ 17203212 (CAS 821768-06-3) References
- Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. | Swanson, DM., et al. 2005. J Med Chem. 48: 1857-72. PMID: 15771431
- Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. | Ghilardi, JR., et al. 2005. J Neurosci. 25: 3126-31. PMID: 15788769
- Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. | Bhattacharya, A., et al. 2007. J Pharmacol Exp Ther. 323: 665-74. PMID: 17690251
- Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder. | Cefalu, JS., et al. 2009. J Urol. 182: 776-85. PMID: 19539322
- TRPV1 splice variants: structure and function. | Schumacher, MA. and Eilers, H. 2010. Front Biosci (Landmark Ed). 15: 872-82. PMID: 20515731
- A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats. | Wiskur, BJ., et al. 2010. Methods Find Exp Clin Pharmacol. 32: 557-64. PMID: 21132125
- Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. | Kelly, S., et al. 2015. Ann Rheum Dis. 74: 252-9. PMID: 24152419
- Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. | Chen, X., et al. 2014. J Biol Chem. 289: 9600-10. PMID: 24569998
- Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. | Meents, JE., et al. 2015. J Headache Pain. 16: 57. PMID: 26109436
- The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis. | Deng, F., et al. 2021. Gut Microbes. 13: 1-21. PMID: 33779497
Inhibitor of:
NMU-25, Olfr1166, Olfr536, Olfr722, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ 17203212, 10 mg | sc-204024 | 10 mg | $185.00 | |||
| US: Only available in the US | ||||||
JNJ 17203212, 50 mg | sc-204024A | 50 mg | $781.00 | |||
| US: Only available in the US | ||||||