JNJ 10181457 dihydrochloride CAS: 544707-19-9
MF: C20H28N2O.2HCl
MW: 385.37
A membrane permeable histamine H3 receptor antagonist.

JNJ 10181457 dihydrochloride (CAS 544707-19-9)

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Application: A membrane permeable histamine H3 receptor antagonist
CAS Number: 544707-19-9
Molecular Weight: 385.37
Molecular Formula: C20H28N2O.2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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JNJ 10181457 dihydrochloride is a membrane permeable histamine H3 receptor antagonist (pKi = 8.15 and 8.93 for rat and human H3 receptors, respectively). This compound has been found to cause an increase in extracellular norepinephrine and acetylcholine levels but does not stimulate dopamine release in rat frontal cortex models.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and ethanol (25 mM).
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10237424
SMILES :
C1CCN(CC1)CCC#CC2=CC(=CC=C2)CN3CCOCC3.Cl.Cl

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Certificate of Analysis

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