JMJD7 Antibody (11K2): sc-134351
- JMJD7 Antibody (11K2) is a mouse monoclonal IgG2a κ JMJD7 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant JMJD7-PLA2G4B-PLA2G4B protein of human origin
- recommended for detection of JMJD7 and JMJD7-PLA2G4B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JMJD7 Antibody (11K2). This work is in progress.
JMJD7 Antibody (11K2) is a mouse monoclonal IgG2a kappa light chain antibody that detects JMJD7 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-JMJD7 antibody (11K2) is available as a non-conjugated format. JMJD7 plays a pivotal role in regulating chromatin dynamics and gene transcription, primarily through functioning as a histone demethylase. JMJD7 is essential for removing methyl groups from specific lysine residues on histones, which is crucial for maintaining the balance between transcriptionally active and inactive chromatin states. JMJD7′s ability to modulate histone methylation directly influences gene expression patterns and contributes to epigenetic memory governing cell fate decisions. JMJD7 belongs to a larger family of JMJC domain-containing histone demethylases, which are involved in various biological processes, including development and cellular senescence. JMJD7 contains a single JMJC domain and was initially thought to be an alternatively spliced isoform of PLA2G4B, highlighting unique structural characteristics and functional importance in cellular regulation.
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JMJD7 Antibody (11K2) References:
- Histone demethylation by a family of JmjC domain-containing proteins. | Tsukada, Y., et al. 2006. Nature. 439: 811-6. PMID: 16362057
- The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. | Cloos, PA., et al. 2006. Nature. 442: 307-11. PMID: 16732293
- JmjC-domain-containing proteins and histone demethylation. | Klose, RJ., et al. 2006. Nat Rev Genet. 7: 715-27. PMID: 16983801
- JMJD6 is a histone arginine demethylase. | Chang, B., et al. 2007. Science. 318: 444-7. PMID: 17947579
- Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. | Hong, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 18439-44. PMID: 18003914
- Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. | Pfau, R., et al. 2008. Proc Natl Acad Sci U S A. 105: 1907-12. PMID: 18250326
- Histone lysine methyltransferases and demethylases in Plasmodium falciparum. | Cui, L., et al. 2008. Int J Parasitol. 38: 1083-97. PMID: 18299133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JMJD7 Antibody (11K2) | sc-134351 | 100 µg/ml | $333.00 |