Molecular structure of JM 34
JM 34
Application:
JM 34 is a useful alternative to classical COX inhibitors
Purity:
≥97%
Molecular Weight:
216.24
Molecular Formula:
C12H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JM 34 is an anti-inflammatory pyridinylamide that blocks TNF-α production, possibly by interacting with a protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation. JM 34 shows no inhibition of PKC activity in vitro. Can be an alternative to classical cyclooxygenase (COX).
JM 34 References
- Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis. | Bobin-Dubigeon, C., et al. 2001. Eur J Pharmacol. 431: 103-10. PMID: 11716848
- Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons. | Keswani, SC., et al. 2003. Ann Neurol. 54: 287-96. PMID: 12953261
- A new carboxamide compound exerts immuno-suppressive activity by inhibiting dendritic cell maturation. | Carbonnelle, D., et al. 2005. Eur J Immunol. 35: 546-56. PMID: 15668915
- Giant vesicles containing magnetic nanoparticles and quantum dots: feasibility and tracking by fiber confocal fluorescence microscopy. | Beaune, G., et al. 2007. Angew Chem Int Ed Engl. 46: 5421-4. PMID: 17562546
- An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages. | Vernhet, L., et al. 1997. J Pharmacol Exp Ther. 283: 358-65. PMID: 9336344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JM 34, 10 mg | sc-221778 | 10 mg | $200.00 | |||
JM 34, 50 mg | sc-221778A | 50 mg | $500.00 |