Molecular structure of JG-98, CAS Number: 1456551-16-8
JG-98 (CAS 1456551-16-8)
CAS Number:
1456551-16-8
Molecular Weight:
534.5
Molecular Formula:
C24H21ClN3OS3•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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JG-98 (CAS 1456551-16-8) References
- Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations. | Yaglom, JA., et al. 2018. Sci Rep. 8: 3010. PMID: 29445088
- Author Correction: Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations. | Yaglom, JA., et al. 2018. Sci Rep. 8: 7177. PMID: 29720612
- Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98. | Shao, H. and Gestwicki, JE. 2020. Bioorg Med Chem Lett. 30: 126954. PMID: 31952963
- Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes. | Martin, TG., et al. 2022. J Cell Biochem. 123: 128-141. PMID: 34487557
- Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. | Hong, SK., et al. 2022. Int J Mol Sci. 23: PMID: 35162987
- Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module. | Patel, S., et al. 2022. iScience. 25: 104282. PMID: 35573186
- Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer. | Echtenkamp, FJ., et al. 2023. PNAS Nexus. 2: pgad115. PMID: 37091547
- Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation. | Hill, SE., et al. 2023. ACS Chem Biol. 18: 1124-1135. PMID: 37144894
- An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3. | Thompson, AD., et al. 2023. JACC Basic Transl Sci. 8: 1198-1211. PMID: 37791314
- BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy. | Martin, TG., et al. 2024. Am J Physiol Heart Circ Physiol. 326: H1124-H1130. PMID: 38488519
Inhibitor of:
Apg-2 (HSPA4), DnaJB3, DnaJC15, ERdj4, Heat shock protein family A (Hsp70), HSP 70, HSPB9, HSPC159, Kar2, and TRAP-1.Activator of:
DnaJB6, and DnaJC7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JG-98, 5 mg | sc-507517 | 5 mg | $224.00 |