Molecular structure of JC-1 iodide, CAS Number: 3520-43-2
JC-1 iodide (CAS 3520-43-2)
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Alternate Names:
JC-1 iodide is also known as CBIC2(3).
Application:
JC-1 iodide is a mitochondrial membrane potential dye and fluorescent probe used to test Pgp activity.
CAS Number:
3520-43-2
Purity:
≥98%
Molecular Weight:
652.23
Molecular Formula:
C25H27Cl4N4•I
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JC-1 is used to determine mitochondrial membrane potential. JC-1 iodide is a cationic carbocyanine dye that is membrane permeable and is often used for flow cytometry and fluorescent microscopy. JC-1 iodide changes color as the membrane potential increases. At higher potentials, JC-1 iodide forms aggregates, which changes the fluorescence emission color from green to red. JC-1 iodide is also known as CBIC2(3), 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-1H-benzimidazolium, monoiodide, and 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide.
JC-1 iodide (CAS 3520-43-2) References
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- Development of signaling echo method for cell-based quantitative efficacy evaluation of anti-cancer drugs in apoptosis without drug presence using high-precision surface plasmon resonance sensing. | Nishijima, H., et al. 2010. Anal Sci. 26: 529-34. PMID: 20467125
- Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo. | Murugan, RS., et al. 2010. Food Chem Toxicol. 48: 3281-7. PMID: 20828598
- Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells. | Kavitha, K., et al. 2012. Eur J Pharmacol. 681: 6-14. PMID: 22327045
- Effect of mitochondrial uncoupling and glycolysis inhibition on ram sperm functionality. | Losano, J., et al. 2017. Reprod Domest Anim. 52: 289-297. PMID: 28058736
- Gedunin, A Neem Limonoid in Combination with Epalrestat Inhibits Cancer Hallmarks by Attenuating Aldose Reductase-Driven Oncogenic Signaling in SCC131 Oral Cancer Cells. | Tanagala, KKK., et al. 2018. Anticancer Agents Med Chem. 18: 2042-2052. PMID: 30062975
- Effects of Brimonidine on Retinal Pigment Epithelial Cells and Müller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro. | Tsao, SW., et al. 2018. Ophthalmic Surg Lasers Imaging Retina. 49: S23-S28. PMID: 30339264
- Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF-κΒ/STAT3 signalling axis in oral squamous cell carcinoma models. | Kowshik, J., et al. 2019. IUBMB Life. 71: 1595-1610. PMID: 31251469
- Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction. | Zhao, T., et al. 2020. Oxid Med Cell Longev. 2020: 1904609. PMID: 32724489
- Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal. | Ito, A., et al. 2021. Int J Mol Sci. 22: PMID: 34205320
- Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia. | Liu, B., et al. 2022. Phytother Res. 36: 2223-2235. PMID: 35419891
- Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. | Congiu, L., et al. 2022. Int J Mol Sci. 23: PMID: 35457156
- StarD7 deficiency hinders cell motility through p-ERK1/2/Cx43 reduction. | Cruz Del Puerto, M., et al. 2022. PLoS One. 17: e0279912. PMID: 36584213
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JC-1 iodide, 1 mg | sc-364116 | 1 mg | $167.00 | |||
JC-1 iodide, 5 mg | sc-364116A | 5 mg | $367.00 |