JAM-A Antibody (J3F.1): sc-53622
- JAM-A Antibody (J3F.1) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against recombinant JAM fusion protein of human origin
- recommended for detection of JAM-A of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See JAM-A (J10.4): sc-53623 for JAM-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for JAM-A Antibody (J3F.1) for WB and IHC(P) applications. These reagents are now offered in bundles with JAM-A Antibody (J3F.1) (see ordering information below).
JAM-A Antibody (J3F.1) is a mouse monoclonal IgG1 kappa light chain antibody raised against a recombinant JAM fusion protein of human origin, specifically reactive with JAM-A of human origin in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Junctional Adhesion Molecule A (JAM-A), also known as JAM-1 or F11 Receptor (F11R), is a member of the immunoglobulin superfamily prominently expressed at tight junctions of epithelial and endothelial cells. JAM-A undergoes post-translational modifications such as phosphorylation and glycosylation, which are crucial for its function in cell adhesion, migration, and signaling. These modifications regulate JAM-A localization and interactions, affecting tight junction integrity and vascular permeability. JAM-A phosphorylation can modulate tight junction assembly and leukocyte transmigration, while glycosylation affects JAM-A cell surface expression and homophilic interactions. JAM-A plays a significant role in cell-to-cell adhesion through homophilic interactions and is involved in leukocyte extravasation during inflammatory responses. JAM-A is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets, and platelets, highlighting JAM-A importance in the immune system. By associating with F-actin at cell-cell contacts and membrane ruffles, JAM-A influences cytoskeletal organization and cellular motility. Anti-JAM-A antibody (J3F.1) provides researchers with a specific and reliable tool to study JAM-A function, post-translational modifications, and their impact on physiological processes such as tight junction organization and immune cell trafficking.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAM-A Antibody (J3F.1) | sc-53622 | 200 µg/ml | $316.00 | |||
JAM-A Antibody (J3F.1): m-IgG Fc BP-HRP Bundle | sc-538999 | 200 µg Ab; 10 µg BP | $354.00 | |||
JAM-A Antibody (J3F.1): m-IgG1 BP-HRP Bundle | sc-541200 | 200 µg Ab; 20 µg BP | $354.00 | |||
JAM-A Antibody (J3F.1) FITC | sc-53622 FITC | 200 µg/ml | $330.00 | |||
JAM-A Antibody (J3F.1) PE | sc-53622 PE | 200 µg/ml | $343.00 |