Molecular structure of JAK3 Inhibitor VII, AD412, CAS Number: 796041-65-1
JAK3 Inhibitor VII, AD412 (CAS 796041-65-1)
See product citations (2)
Alternate Names:
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
Application:
JAK3 Inhibitor VII, AD412 is a selective inhibitor of JAK3
CAS Number:
796041-65-1
Molecular Weight:
389.88
Molecular Formula:
C23H20ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
JAK3 Inhibitor VII, AD412 is a cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit JAK3 kinase activity (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1 and JAK3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. JAK3 Inhibitor VII, AD412 is reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro.
Inhibitor of:
JAK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK3 Inhibitor VII, AD412, 25 mg | sc-364727 | 25 mg | $200.00 |