Molecular structure of JAK3 Inhibitor VI, CAS Number: 856436-16-3
JAK3 Inhibitor VI (CAS 856436-16-3)
Alternate Names:
(3Z)-5-(3-Pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one methanesulfonate
Application:
JAK3 Inhibitor VI is a cell permeable selective inhibitor of JAK3
CAS Number:
856436-16-3
Molecular Weight:
383.42
Molecular Formula:
C18H13N3O•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JAK3 Inhibitor VI is a cell-permeable 3′-pyridyl oxindole compound that acts as a potent inhibitor of JAK3. JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription.
JAK3 Inhibitor VI (CAS 856436-16-3) References
- Mapping the kinase domain of Janus Kinase 3. | Adams, C., et al. 2003. Bioorg Med Chem Lett. 13: 3105-10. PMID: 12941344
- Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. | Chen, JJ., et al. 2006. Bioorg Med Chem Lett. 16: 5633-8. PMID: 16934457
- Identification of an orally available compound with potent and broad FLT3 inhibition activity. | Chen, Y., et al. 2016. Oncogene. 35: 2971-8. PMID: 26411368
- Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors. | Falk, MD., et al. 2014. Biosci Rep. 34: PMID: 27919031
- Kinase Inhibitors with Antiepileptic Properties Identified with a Novel in Vitro Screening Platform. | Liu, J., et al. 2019. Int J Mol Sci. 20: PMID: 31117204
- Biomechanical regulation of breast cancer metastasis and progression. | Spencer, A., et al. 2021. Sci Rep. 11: 9838. PMID: 33972619
Inhibitor of:
Enzyme, and JAK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK3 Inhibitor VI, 5 mg | sc-204022 | 5 mg | $242.00 | |||
JAK3 Inhibitor VI, 10 mg | sc-204022A | 10 mg | $458.00 | |||
JAK3 Inhibitor VI, 50 mg | sc-204022B | 50 mg | $1144.00 | |||
JAK3 Inhibitor VI, 100 mg | sc-204022C | 100 mg | $2081.00 | |||
JAK3 Inhibitor VI, 500 mg | sc-204022D | 500 mg | $8323.00 |