Molecular structure of JAK2 Inhibitor V, Z3, CAS Number: 195371-52-9
JAK2 Inhibitor V, Z3 (CAS 195371-52-9)
Application:
JAK2 Inhibitor V, Z3 is a JAK2 inhibitor
CAS Number:
195371-52-9
Purity:
≥99%
Molecular Weight:
344.5
Molecular Formula:
C23H24N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2 autophosphorylation in COS cells or SRC in cell-free kinase assays. JAK2 Inhibitor V, Z3 suppresses the JAK2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.
Inhibitor of:
JAK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK2 Inhibitor V, Z3, 10 mg | sc-221775 | 10 mg | $178.00 |