Molecular structure of JAK2 Inhibitor III, SD-1029, CAS Number: 118372-34-2
JAK2 Inhibitor III, SD-1029 (CAS 118372-34-2)
See product citations (5)
Alternate Names:
9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr
Application:
JAK2 Inhibitor III, SD-1029 is a selective JAK2 inhibitor
CAS Number:
118372-34-2
Purity:
≥80%
Molecular Weight:
639.25
Molecular Formula:
C25H30Cl2N2O3•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JAK2 Inhibitor III, SD-1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. Has been shown to display a lower effect on the cellular phosphorylation levels of Jak1 and Src and shows little inhibition towards a panel of 49 other protein kinases in cell-free kinase assays. JAK2 Inhibitor III, SD-1029 has been shown to effectively inhibit cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.
JAK2 Inhibitor III, SD-1029 (CAS 118372-34-2) References
- SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. | Duan, Z., et al. 2006. Clin Cancer Res. 12: 6844-52. PMID: 17121906
- Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils. | Andina, N., et al. 2009. J Allergy Clin Immunol. 123: 603-11. PMID: 19152965
- A novel target for treatment of chordoma: signal transducers and activators of transcription 3. | Yang, C., et al. 2009. Mol Cancer Ther. 8: 2597-605. PMID: 19723879
- Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. | Che Mat, NF., et al. 2011. J Interferon Cytokine Res. 31: 363-71. PMID: 21138378
- XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. | Liu, Y., et al. 2011. Apoptosis. 16: 502-10. PMID: 21311975
- Suppression of La antigen exerts potential antiviral effects against hepatitis A virus. | Jiang, X., et al. 2014. PLoS One. 9: e101993. PMID: 24999657
- Pre-stroke seizures: A nationwide register-based investigation. | Zelano, J., et al. 2017. Seizure. 49: 25-29. PMID: 28544888
- Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades. | Chen, X., et al. 2020. Mol Neurobiol. 57: 4305-4321. PMID: 32700252
- γ-Secretase inhibitor alleviates lipopolysaccharide-induced myocardial injury through regulating JAK2/STAT3 signaling. | Fang, J. and Guan, H. 2024. Environ Toxicol. 39: 135-147. PMID: 37671635
- Low-Density Lipoprotein Contributes to Endometrial Carcinoma Cell Proliferation, Migration, and Invasion by Activating the JAK-STAT Signaling Pathway. | Shen, L., et al. 2023. Anal Cell Pathol (Amst). 2023: 4015167. PMID: 37900720
Inhibitor of:
JAK, and JAK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK2 Inhibitor III, SD-1029, 10 mg | sc-221773 | 10 mg | $278.00 |