J774.A1 Cell Lysate: sc-3802

J774.A1 Cell Lysate is produced from the J774.A1 cell line, a widely used murine macrophage cell line derived from a reticulum cell sarcoma, a type of cancer that affects cells in the immune system. This cell line is particularly valuable in immunological research because it exhibits many of the functional properties of macrophages, including phagocytosis and the secretion of biologically important molecules. The lysate itself is obtained by lysing J774.A1 cells, thereby releasing a comprehensive array of cellular constituents such as proteins, nucleic acids, lipids, and various metabolites. These components are critical for understanding the biochemical and signaling pathways active within macrophages. Researchers utilize J774.A1 Cell Lysate in a variety of research applications to study macrophage biology, including the cellular response to infections, the activation state of macrophages, and the interaction between macrophages and pathogens. The lysate has also been instrumental in exploring the intracellular signaling mechanisms that govern macrophage activation and response to inflammatory stimuli. By providing a deep dive into the molecular machinery of macrophages, J774.A1 Cell Lysate contributes significantly to the field of immunology, aiding in the understanding of innate immune responses and macrophage-mediated processes in health and disease states.

J774.A1 Cell Lysate References:

1. Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides.  |  Headlam, HA., et al. 2006. Free Radic Biol Med. 40: 1539-48. PMID: 16632114