Date published: 2026-5-15

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J 104129 fumarate (CAS 244277-89-2)

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Alternate Names:
(αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate
Application:
J 104129 fumarate is a mAChR M3 antagonist
CAS Number:
244277-89-2
Purity:
≥99%
Molecular Weight:
500.63
Molecular Formula:
C24H36N2O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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J 104129, commonly referred to as Flesinoxan, a chemical compound that acts as a potent and selective agonist for the serotonin 5-HT1A receptor. J 104129 is structurally related to the quinolone family, which is evident in its core quinolone ring system. Flesinoxan′s action as a 5-HT1A receptor agonist involves the stimulation of these receptors, which are part of the serotonin neurotransmitter system and are implicated in regulating various neurological processes. In scientific studies, Flesinoxan is often used to explore the role of 5-HT1A receptors in behavior and physiological responses. Its selective activation of these receptors helps to understand their involvement in mood, anxiety, cognition, and other functions of the central nervous system. The compound may be useful for dissecting the pathways and mechanisms through which serotonin modulates these diverse processes. While Flesinoxan is primarily recognized for its receptor targeting properties, it also serves as a valuable compound in neuropharmacology research, helping to identify potential therapeutic targets and understand the complexities of neurotransmitter interactions.


J 104129 fumarate (CAS 244277-89-2) References

  1. Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp.  |  Sterin-Borda, L., et al. 2011. J Endod. 37: 185-90. PMID: 21238800
  2. BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization.  |  Semenov, I., et al. 2011. J Physiol. 589: 1803-17. PMID: 21300746
  3. Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans.  |  Rodriguez-Diaz, R., et al. 2011. Nat Med. 17: 888-92. PMID: 21685896
  4. Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.  |  Tian, MK., et al. 2011. J Neurosci. 31: 16458-63. PMID: 22072695
  5. GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease.  |  Zhang, X., et al. 2014. J Neurochem. 129: 581-90. PMID: 24475872
  6. The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.  |  Pannell, M., et al. 2016. Brain Struct Funct. 221: 1157-72. PMID: 25523105
  7. Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling.  |  DeMazumder, D., et al. 2015. Circ Res. 116: 1691-9. PMID: 25733594
  8. Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.  |  Ho, HT., et al. 2016. Hypertension. 68: 1171-1178. PMID: 27647848
  9. Muscarinic cholinoreceptors (M1-, M2-, M3- and M4-type) modulate the acetylcholine secretion in the frog neuromuscular junction.  |  Tsentsevitsky, AN., et al. 2017. Neurosci Lett. 649: 62-69. PMID: 28408330

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

J 104129 fumarate, 10 mg

sc-203610
10 mg
$215.00
US: Only available in the US