Ivermectin-d2 (CAS 70288-86-7 unlabeled)
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Ivermectin-d2 is a deuterated variant of ivermectin, where two hydrogen atoms are replaced with deuterium. This compound is primarily utilized in analytical studies to better understand the kinetic properties of ivermectin. Research involving Ivermectin-d2 often focuses on its behavior in biological matrices, and its deuterated form allows for differential analysis when distinguishing the compound from endogenous substances or other similar compounds in mass spectrometry. The use of Ivermectin-d2 in environmental studies also provides insights into the degradation and persistence of ivermectin in various ecosystems, as the deuterated form can be more easily tracked. Additionally, Ivermectin-d2 is valuable in the field of entomology, where it is used to study the effects on parasites and vectors at a molecular level, without the influence of metabolic processes that affect the non-deuterated form.
Ivermectin-d2 (CAS 70288-86-7 unlabeled) References
- On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. | de Oliveira Ferreira, F., et al. 2016. J Chromatogr A. 1471: 118-125. PMID: 27745927
- Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers. | Duthaler, U., et al. 2019. Br J Clin Pharmacol. 85: 626-633. PMID: 30566757
- Development and validation of an LC-MS/MS method for the analysis of ivermectin in plasma, whole blood, and dried blood spots using a fully automatic extraction system. | Duthaler, U., et al. 2019. J Pharm Biomed Anal. 172: 18-25. PMID: 31015095
- Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques. | Vanachayangkul, P., et al. 2020. Antimicrob Agents Chemother. 64: PMID: 32660993
- Safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine, and chloroquine in Rhesus macaques. | Vanachayangkul, P., et al. 2024. Antimicrob Agents Chemother. e0018124. PMID: 38742896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ivermectin-d2, 1 mg | sc-495570 | 1 mg | $357.00 | |||
Ivermectin-d2, 10 mg | sc-495570A | 10 mg | $2458.00 | |||
Ivermectin-d2, 50 mg | sc-495570B | 50 mg | $9868.00 |