Molecular structure of Ivermectin aglycone, CAS Number: 123997-59-1
Ivermectin aglycone (CAS 123997-59-1)
See product citations (5)
Alternate Names:
Dihydroavermectin B1 aglycone; Ivermectin B1 aglycone
Application:
Ivermectin aglycone is a potent inhibitor of nematode larval development but is devoid of paralytic activity
CAS Number:
123997-59-1
Purity:
>99%
Molecular Weight:
586.8
Molecular Formula:
C34H50O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ivermectin aglycone is a semi-synthetic produced by the hydrolysis of the disaccharide unit of ivermectin. This product is shown to be a potent inhibitor of nematode larval development but is devoid of paralytic activity. The aglycone may act to be used as a sensitive probe for the detection of some types of ivermectin resistance.
Ivermectin aglycone (CAS 123997-59-1) References
- High-level ivermectin resistance in a field isolate of Haemonchus contortus associated with a low level of resistance in the larval stage: implications for resistance detection. | Kotze, AC., et al. 2002. Vet Parasitol. 108: 255-63. PMID: 12237144
- Effects of macrocyclic lactone anthelmintics on feeding and pharyngeal pumping in Trichostrongylus colubriformis in vitro. | Sheriff, JC., et al. 2002. Parasitology. 125: 477-84. PMID: 12458832
- Larval development assay for detection of anthelmintic resistance in cyathostomins of Swedish horses. | Lind, EO., et al. 2005. Vet Parasitol. 128: 261-9. PMID: 15740863
- The difference in efficacy of ivermectin oral, moxidectin oral and moxidectin injectable formulations against an ivermectin-resistant strain of Trichostrongylus colubriformis in sheep. | Gopal, RM., et al. 2001. N Z Vet J. 49: 133-7. PMID: 16032180
- Detection of resistance to ivermectin in Haemonchus contortus. | Gill, JH., et al. 1991. Int J Parasitol. 21: 771-6. PMID: 1774112
- Is the micro-agar larval development test reliable enough to detect ivermectin resistance? | Dolinská, M., et al. 2012. Parasitol Res. 111: 2201-4. PMID: 22581298
- Relative potency of macrocyclic lactones in in vitro assays with larvae of susceptible and drug-resistant Australian isolates of Haemonchus contortus and H. placei. | Kotze, AC., et al. 2014. Vet Parasitol. 203: 294-302. PMID: 24813746
- In silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1. | David, MA., et al. 2016. Int J Parasitol Drugs Drug Resist. 6: 299-313. PMID: 27746191
- P-glycoproteins play a role in ivermectin resistance in cyathostomins. | Peachey, LE., et al. 2017. Int J Parasitol Drugs Drug Resist. 7: 388-398. PMID: 29121562
- Development of resistance to eprinomectin in gastrointestinal nematodes in a goat herd with pre-existing resistance to benzimidazoles. | Mickiewicz, M., et al. 2019. Pol J Vet Sci. 22: 753-760. PMID: 31867918
- Comparative Evaluation of Two In Vitro Tests for Detection of Ivermectin Resistance in Haemonchus contortus of Small Ruminants in Uttar Pradesh, India. | Singh, E., et al. 2021. Acta Parasitol. 66: 1565-1569. PMID: 33914239
- First Report of Anthelmintic Resistance in Gastrointestinal Nematodes in Goats in Romania. | Potârniche, AV., et al. 2021. Animals (Basel). 11: PMID: 34679782
- Ivermectin, a new broad-spectrum antiparasitic agent. | Chabala, JC., et al. 1980. J Med Chem. 23: 1134-6. PMID: 6893469
- Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | Schulman, M., et al. 1993. Antimicrob Agents Chemother. 37: 1737-41. PMID: 8239577
- First records of Amblyomma americanum, Ixodes (Ixodes) dentatus, and Ixodes (Ceratixodes) uriae (Acari: Ixodidae) from Maine. | Keirans, JE. and Lacombe, EH. 1998. J Parasitol. 84: 629-31. PMID: 9645873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ivermectin aglycone, 1 mg | sc-202189 | 1 mg | $305.00 |