Date published: 2026-5-16

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ivachtin (CAS 745046-84-8)

5.0(1)
Write a reviewAsk a question

Alternate Names:
2-[4-Methyl-8-(morpholin-4-ylsulfon yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
Application:
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3
CAS Number:
745046-84-8
Molecular Weight:
447.47
Molecular Formula:
C20H21N3O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ivachtin is a chemical compound that is utilized in various applications, particularly in studies related to its properties as a ligand. In biochemistry and molecular biology, Ivachtin investigates the binding interactions between ligands and their respective receptors or proteins. Ivachtin can be used to explore the dynamics of receptor-ligand interactions, which are fundamental for understanding signaling pathways and molecular recognition processes. Ivachtin, for studying the structure-activity relationships in complexes formed with biological macromolecules, which can shed light on the design of new compounds with specific binding characteristics. Ivachtin′s interactions with proteins or receptors can be monitored and quantified to gain insights into the kinetics and thermodynamics of binding events, aiding in the elucidation of cellular communication mechanisms.


Ivachtin (CAS 745046-84-8) References

  1. Inactin concentration in plasma of rats during anaesthesia and the effect of this concentration on short circuit current of isolated frog skin.  |  Häberle, DA. and Ruhland, G. 1976. Pflugers Arch. 365: 77-80. PMID: 1086459
  2. The effect on total renal and tubular function and plasma renin of a moderate isotonic saline load in rats anesthetized with amytal and inactin.  |  Leyssac, PP., et al. 1975. Acta Physiol Scand. 94: 472-83. PMID: 1180088
  3. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.  |  Kravchenko, DV., et al. 2005. J Med Chem. 48: 3680-3. PMID: 15916416
  4. Gastric emptying of enterally administered liquid meal in conscious rats and during sustained anaesthesia.  |  Qualls-Creekmore, E., et al. 2010. Neurogastroenterol Motil. 22: 181-5. PMID: 19735361
  5. Caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion.  |  Gauster, M., et al. 2010. Cell Death Differ. 17: 336-45. PMID: 19798107
  6. Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.  |  Karwi, QG., et al. 2016. Pharmacol Res. 111: 442-451. PMID: 27378570
  7. EEG in anaesthetized rats.  |  Sim, MK. and Chua, ME. 1989. Pharmacol Toxicol. 65: 119-20. PMID: 2813283
  8. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.  |  Menon, MB., et al. 2017. Nat Cell Biol. 19: 1248-1259. PMID: 28920954
  9. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.  |  Yosefzon, Y., et al. 2018. Mol Cell. 70: 573-587.e4. PMID: 29775577
  10. The effect of inactin on kidney mitochondrial function and production of reactive oxygen species.  |  Schiffer, TA., et al. 2018. PLoS One. 13: e0207728. PMID: 30475856
  11. Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage.  |  Xiang, L., et al. 2020. J Trauma Acute Care Surg. 89: S93-S99. PMID: 32044869
  12. Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity.  |  DeLalio, LJ. and Stocker, SD. 2021. Am J Physiol Heart Circ Physiol. 320: H117-H132. PMID: 33216622
  13. Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys.  |  Zhao, F., et al. 2021. NMR Biomed. 34: e4566. PMID: 34096123
  14. Analysis of adrenergic effects of the anesthetics Inactin and alpha-chloralose.  |  Tucker, BJ., et al. 1982. Am J Physiol. 243: F253-9. PMID: 7114255

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ivachtin, 1 mg

sc-224029
1 mg
$122.00

Ivachtin, 5 mg

sc-224029A
5 mg
$235.00