Molecular structure of Ivabradine Hydrochloride, CAS Number: 148849-67-6
Ivabradine Hydrochloride (CAS 148849-67-6)
See product citations (2)
Application:
Ivabradine Hydrochloride is a selective bradycardic agent
CAS Number:
148849-67-6
Purity:
≥99%
Molecular Weight:
505.05
Molecular Formula:
C27H36N2O5 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ivabradine Hydrochloride, also known as S-16257, is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolaryzation-activated I(f) current without resulting in a shift of the voltage range of the activation curve.
Ivabradine Hydrochloride (CAS 148849-67-6) References
- Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. | Borer, JS., et al. 2003. Circulation. 107: 817-23. PMID: 12591750
- Ivabradine reduces chemokine-induced CD4-positive lymphocyte migration. | Walcher, T., et al. 2010. Mediators Inflamm. 2010: 751313. PMID: 21188276
- Effects of ivabradine hydrochloride combined with trimetazidine on myocardial fibrosis in rats with chronic heart failure. | Ma, D., et al. 2019. Exp Ther Med. 18: 1639-1644. PMID: 31410120
- Micellar-emphasized simultaneous determination of ivabradine hydrochloride and felodipine using synchronous spectrofluorimetry. | Yosrey, E., et al. 2022. Luminescence. 37: 569-576. PMID: 34995408
- Formulation, optimization and validation of floating oral in situ gel of Ivabradine hydrochloride. | Desai, D., et al. 2022. Ther Deliv. 13: 283-294. PMID: 35615867
- Label-free green estimation of atenolol and ivabradine hydrochloride in pharmaceutical and biological matrices by synchronous spectrofluorimetry. | Aboshabana, R., et al. 2023. Spectrochim Acta A Mol Biomol Spectrosc. 295: 122626. PMID: 36940537
- The efficacy and safety of ivabradine hydrochloride in hemodialysis patients with chronic heart failure. | Kawasaki, S., et al. 2024. Ther Apher Dial. 28: 354-363. PMID: 38199237
- Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. | Thollon, C., et al. 1994. Br J Pharmacol. 112: 37-42. PMID: 8032660
- Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. | Bois, P., et al. 1996. Br J Pharmacol. 118: 1051-7. PMID: 8799581
- Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. | Ragueneau, I., et al. 1998. Clin Pharmacol Ther. 64: 192-203. PMID: 9728900
Inhibitor of:
Carnitine Acetyltransferase, HCN1, HCN4, and Troponin I-C.Activator of:
RAMP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ivabradine Hydrochloride, 10 mg | sc-211682 | 10 mg | $250.00 |