Molecular structure of ITSA1, CAS Number: 200626-61-5
ITSA1 (CAS 200626-61-5)
See product citations (4)
Alternate Names:
N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
Application:
ITSA1 is an HDAC activator via TSA suppression
CAS Number:
200626-61-5
Purity:
≥95%
Molecular Weight:
292.12
Molecular Formula:
C13H7Cl2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.
ITSA1 (CAS 200626-61-5) References
- Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. | Haggarty, SJ., et al. 2003. Proc Natl Acad Sci U S A. 100: 4389-94. PMID: 12677000
- Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. | Haggarty, SJ., et al. 2003. Chem Biol. 10: 383-96. PMID: 12770821
- Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. | Koeller, KM., et al. 2003. Chem Biol. 10: 397-410. PMID: 12770822
- Small molecule modulation of the human chromatid decatenation checkpoint. | Haggarty, SJ., et al. 2003. Chem Biol. 10: 1267-79. PMID: 14700634
- p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. | Devgan, V., et al. 2005. Genes Dev. 19: 1485-95. PMID: 15964998
- Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. | Iliev, AI., et al. 2009. Mol Microbiol. 71: 461-77. PMID: 19040644
- Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications. | Peng, YT., et al. 2015. Toxicol Rep. 2: 322-332. PMID: 28962365
- HDAC6 promotes sepsis development by impairing PHB1-mediated mitochondrial respiratory chain function. | Guo, SD., et al. 2020. Aging (Albany NY). 12: 5411-5422. PMID: 32221047
- Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway. | Kershaw, S., et al. 2020. J Cell Sci. 133: PMID: 32381682
- Maintenance of HDACs and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage. | Wang, TY., et al. 2021. Front Cell Dev Biol. 9: 642150. PMID: 33898431
- Acceleration of ageing via disturbing mTOR-regulated proteostasis by a new ageing-associated gene PC4. | Chen, L., et al. 2021. Aging Cell. 20: e13370. PMID: 33957702
- Terpyridine Zn(II) Complexes with Azide Units for Visualization of Histone Deacetylation in Living Cells under STED Nanoscopy. | Du, W., et al. 2021. ACS Sens. 6: 3978-3984. PMID: 34498846
- An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. | Lesage, R., et al. 2022. BMC Biol. 20: 253. PMID: 36352408
- Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK. | Xie, Z., et al. 2023. Inflamm Res. 1-24. PMID: 36640195
- Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. | Hoshikawa, Y., et al. 1994. Exp Cell Res. 214: 189-97. PMID: 8082721
Activator of:
HDAC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITSA1, 10 mg | sc-200894B | 10 mg | $66.00 | |||
ITSA1, 25 mg | sc-200894 | 25 mg | $107.00 | |||
ITSA1, 100 mg | sc-200894A | 100 mg | $311.00 |