Molecular structure of Isradipine Lactone
Isradipine Lactone
Application:
Isradipine Lactone is a cyclic ester derivative of Isradipine
Molecular Weight:
355.34
Molecular Formula:
C18H17N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isradipine Lactone is a derivative of Isradipine. Isradipine is a 2,4-dihydropyridine, selective agonist of L-type Ca2+ channels. Research has indicated that Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro . Additional studies indicate that Isradipine may provide a neuroprotective effect and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Isradipine Lactone References
- Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia. | Chandra, S., et al. 1999. Pharmacology. 58: 292-9. PMID: 10325574
- Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia. | Bracht, C., et al. 2001. J Hypertens. 19: 899-905. PMID: 11393673
- The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson′s disease. | Ilijic, E., et al. 2011. Neurobiol Dis. 43: 364-71. PMID: 21515375
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isradipine Lactone, 10 mg | sc-280868 | 10 mg | $4212.00 |